Sudha K Pai
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Explore the profile of Sudha K Pai including associated specialties, affiliations and a list of published articles.
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19
Citations
1706
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Recent Articles
1.
Xing F, Kobayashi A, Okuda H, Watabe M, Pai S, Pandey P, et al.
EMBO Mol Med
. 2013 Mar;
5(3):384-96.
PMID: 23495140
Brain metastasis of breast cancer profoundly affects the cognitive and sensory functions as well as morbidity of patients, and the 1 year survival rate among these patients remains less than...
2.
Okuda H, Xing F, Pandey P, Sharma S, Watabe M, Pai S, et al.
Cancer Res
. 2013 Feb;
73(4):1434-44.
PMID: 23384942
Despite significant improvement in survival rates of patients with breast cancer, prognosis of metastatic disease is still dismal. Cancer stem-like cells (CSC) are considered to play a role in metastatic...
3.
Liu W, Xing F, Iiizumi-Gairani M, Okuda H, Watabe M, Pai S, et al.
EMBO Mol Med
. 2012 Jan;
4(2):93-108.
PMID: 22246988
Wnt signalling has pivotal roles in tumour progression and metastasis; however, the exact molecular mechanism of Wnt signalling in the metastatic process is as yet poorly defined. Here we demonstrate...
4.
Kobayashi A, Okuda H, Xing F, Pandey P, Watabe M, Hirota S, et al.
J Exp Med
. 2011 Nov;
208(13):2641-55.
PMID: 22124112
Metastatic disease is the major cause of cancer deaths, and recurrent tumors at distant organs are a critical issue. However, how metastatic tumor cells become dormant and how and why...
5.
Okuda H, Kobayashi A, Xia B, Watabe M, Pai S, Hirota S, et al.
Cancer Res
. 2011 Nov;
72(2):537-47.
PMID: 22113945
The molecular mechanisms that operate within the organ microenvironment to support metastatic progression remain unclear. Here, we report that upregulation of hyaluronan synthase 2 (HAS2) occurs in highly metastatic breast...
6.
Liu W, Iiizumi-Gairani M, Okuda H, Kobayashi A, Watabe M, Pai S, et al.
J Biol Chem
. 2011 Apr;
286(21):18949-59.
PMID: 21454613
NDRG1 and KAI1 belong to metastasis suppressor genes, which impede the dissemination of tumor cells from primary tumors to distant organs. Previously, we identified the metastasis promoting transcription factor, ATF3,...
7.
Pandey P, Okuda H, Watabe M, Pai S, Liu W, Kobayashi A, et al.
Breast Cancer Res Treat
. 2010 Dec;
130(2):387-98.
PMID: 21188630
Resveratrol is a natural polyphenolic compound and has been shown to exhibit cardio-protective as well as anti-neoplastic effects on various types of cancers. However, the exact mechanism of its anti-tumor...
8.
Liu W, Furuta E, Shindo K, Watabe M, Xing F, Pandey P, et al.
Breast Cancer Res Treat
. 2010 Jul;
128(1):57-68.
PMID: 20665104
We previously isolated cacalol as a free radical-scavenging compound from Cacalia delphiniifolia which is a traditional Asian herbal plant and is believed to have medicinal effects on cancer. In this...
9.
Iiizumi M, Bandyopadhyay S, Pai S, Watabe M, Hirota S, Hosobe S, et al.
Cancer Res
. 2008 Sep;
68(18):7613-20.
PMID: 18794150
RhoC is a member of the Ras-homologous family of genes which have been implicated in tumorigenesis and tumor progression. However, the exact role of RhoC is controversial and is yet...
10.
Drug development against metastasis-related genes and their pathways: a rationale for cancer therapy
Iiizumi M, Liu W, Pai S, Furuta E, Watabe K
Biochim Biophys Acta
. 2008 Aug;
1786(2):87-104.
PMID: 18692117
It is well recognized that the majority of cancer related deaths is caused by metastatic diseases. Therefore, there is an urgent need for the development of therapeutic intervention specifically targeted...