Sudarsanareddy Lokireddy
Overview
Explore the profile of Sudarsanareddy Lokireddy including associated specialties, affiliations and a list of published articles.
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20
Citations
779
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Recent Articles
1.
VerPlank J, Lokireddy S, Zhao J, Goldberg A
Proc Natl Acad Sci U S A
. 2019 Feb;
116(10):4228-4237.
PMID: 30782827
Pharmacological agents that raise cAMP and activate protein kinase A (PKA) stimulate 26S proteasome activity, phosphorylation of subunit Rpn6, and intracellular degradation of misfolded proteins. We investigated whether a similar...
2.
VerPlank J, Lokireddy S, Feltri M, Goldberg A, Wrabetz L
Glia
. 2017 Oct;
66(2):379-395.
PMID: 29076578
In several neurodegenerative diseases in which misfolded proteins accumulate there is impairment of the ubiquitin proteasome system (UPS). We tested if a similar disruption of proteostasis occurs in hereditary peripheral...
3.
Bonala S, Lokireddy S, McFarlane C, Patnam S, Sharma M, Kambadur R
J Biol Chem
. 2016 Jul;
291(27):14392.
PMID: 27371568
No abstract available.
4.
Bonala S, Lokireddy S, Arigela H, Teng S, Wahli W, Sharma M, et al.
J Biol Chem
. 2016 Jul;
291(27):14391.
PMID: 27371567
No abstract available.
5.
Lokireddy S, Kukushkin N, Goldberg A
Proc Natl Acad Sci U S A
. 2015 Dec;
112(52):E7176-85.
PMID: 26669444
Although rates of protein degradation by the ubiquitin-proteasome pathway (UPS) are determined by their rates of ubiquitination, we show here that the proteasome's capacity to degrade ubiquitinated proteins is also...
6.
McFarlane C, Vajjala A, Arigela H, Lokireddy S, Ge X, Bonala S, et al.
PLoS One
. 2014 Feb;
9(1):e87687.
PMID: 24498167
Growth factors, such as myostatin (Mstn), play an important role in regulating post-natal myogenesis. In fact, loss of Mstn has been shown to result in increased post-natal muscle growth through...
7.
Bonala S, Lokireddy S, McFarlane C, Patnam S, Sharma M, Kambadur R
J Biol Chem
. 2014 Jan;
289(11):7654-70.
PMID: 24451368
To date a plethora of evidence has clearly demonstrated that continued high calorie intake leads to insulin resistance and type-2 diabetes with or without obesity. However, the necessary signals that...
8.
Sriram S, Subramanian S, Juvvuna P, Ge X, Lokireddy S, McFarlane C, et al.
Mol Endocrinol
. 2014 Jan;
28(3):317-30.
PMID: 24438338
Smad (Sma and Mad-related protein) 2/3 are downstream signaling molecules for TGF-β and myostatin (Mstn). Recently, Mstn was shown to induce reactive oxygen species (ROS) in skeletal muscle via canonical...
9.
Bonala S, McFarlane C, Ang J, Lim R, Lee M, Chua H, et al.
Mol Endocrinol
. 2013 Aug;
27(9):1518-35.
PMID: 23927930
Obesity is associated with insulin resistance and abnormal peripheral tissue glucose uptake. However, the mechanisms that interfere with insulin signaling and glucose uptake in human skeletal muscle during obesity are...
10.
Kukreti H, Amuthavalli K, Harikumar A, Sathiyamoorthy S, Feng P, Anantharaj R, et al.
J Biol Chem
. 2013 Jan;
288(9):6663-78.
PMID: 23297411
High doses of dexamethasone (Dex) or myostatin (Mstn) induce severe atrophy of skeletal muscle. Here we show a novel microRNA1 (miR1)-mediated mechanism through which Dex promotes skeletal muscle atrophy. Using...