Sudarsanareddy Lokireddy
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Explore the profile of Sudarsanareddy Lokireddy including associated specialties, affiliations and a list of published articles.
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20
Citations
779
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Recent Articles
11.
The ubiquitin ligase Mul1 induces mitophagy in skeletal muscle in response to muscle-wasting stimuli
Lokireddy S, Wijesoma I, Teng S, Bonala S, Gluckman P, McFarlane C, et al.
Cell Metab
. 2012 Nov;
16(5):613-24.
PMID: 23140641
Recent research reveals that dysfunction and subsequent loss of mitochondria (mitophagy) is a potent inducer of skeletal muscle wasting. However, the molecular mechanisms that govern the deregulation of mitochondrial function...
12.
Lokireddy S, Wijesoma I, Sze S, McFarlane C, Kambadur R, Sharma M
Am J Physiol Cell Physiol
. 2012 Jun;
303(5):C512-29.
PMID: 22673621
Atrogin-1, a muscle-specific E3 ligase, targets MyoD for degradation through the ubiquitin-proteasome-mediated system. Myostatin, a member of the transforming growth factor-β superfamily, potently inhibits myogenesis by lowering MyoD levels. While...
13.
Lokireddy S, Wijesoma I, Bonala S, Wei M, Sze S, McFarlane C, et al.
Biochem J
. 2012 May;
446(1):23-36.
PMID: 22621320
Humoral and tumoral factors collectively promote cancer-induced skeletal muscle wasting by increasing protein degradation. Although several humoral proteins, namely TNFα (tumour necrosis factor α) and IL (interleukin)-6, have been shown...
14.
Bonala S, Lokireddy S, Arigela H, Teng S, Wahli W, Sharma M, et al.
J Biol Chem
. 2012 Feb;
287(16):12935-51.
PMID: 22362769
Classically, peroxisome proliferator-activated receptor β/δ (PPARβ/δ) function was thought to be restricted to enhancing adipocyte differentiation and development of adipose-like cells from other lineages. However, recent studies have revealed a...
15.
Lokireddy S, McFarlane C, Ge X, Zhang H, Sze S, Sharma M, et al.
Mol Endocrinol
. 2011 Oct;
25(11):1936-49.
PMID: 21964591
Ubiquitination-mediated proteolysis is a hallmark of skeletal muscle wasting manifested in response to negative growth factors, including myostatin. Thus, the characterization of signaling mechanisms that induce the ubiquitination of intracellular...
16.
Lokireddy S, Mouly V, Butler-Browne G, Gluckman P, Sharma M, Kambadur R, et al.
Am J Physiol Cell Physiol
. 2011 Sep;
301(6):C1316-24.
PMID: 21900687
Myostatin is a negative regulator of skeletal muscle growth and in fact acts as a potent inducer of "cachectic-like" muscle wasting in mice. The mechanism of action of myostatin in...
17.
McFarlane C, Hui G, Amanda W, Lau H, Lokireddy S, Xiaojia G, et al.
Am J Physiol Cell Physiol
. 2011 Apr;
301(1):C195-203.
PMID: 21508334
Myostatin, a member of the transforming growth factor-β superfamily, has been implicated in the potent negative regulation of myogenesis in murine models. However, little is known about the mechanism(s) through...
18.
Ge X, McFarlane C, Vajjala A, Lokireddy S, Ng Z, Tan C, et al.
Cell Res
. 2011 Apr;
21(11):1591-604.
PMID: 21502976
TGF-β and myostatin are the two most important regulators of muscle growth. Both growth factors have been shown to signal through a Smad3-dependent pathway. However to date, the role of...
19.
Lokireddy S, Sarojamma V, Ramakrishna V
Virol J
. 2009 Jun;
6:77.
PMID: 19531208
Chikungunya fever is a viral disease transmitted to humans by the bite of CHIKV virus infected Aedes mosquitoes. During monsoon outbreak of chikungunya fever, we carried out the genetic predisposition...
20.
Lokireddy S, Vemula S, Vadde R
Virol J
. 2008 Feb;
5:31.
PMID: 18302795
Background: Chikungunya (CHIK) fever is a viral disease transmitted to humans by the bite of Chikungunya virus (CHIK virus) infected Aedes mosquitoes. CHIK virus is a member of the Alphavirus...