Subramanian Akshay
Overview
Explore the profile of Subramanian Akshay including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
207
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0
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Recent Articles
1.
Akshay S, Bertea M, Hobbie S, Oettinghaus B, Shcherbakov D, Bottger E, et al.
Antimicrob Agents Chemother
. 2011 Jul;
55(9):4096-102.
PMID: 21730122
Antibiotics targeting the bacterial ribosome typically bind to highly conserved rRNA regions with only minor phylogenetic sequence variations. It is unclear whether these sequence variations affect antibiotic susceptibility or resistance...
2.
Hobbie S, Akshay S, Kalapala S, Bruell C, Shcherbakov D, Bottger E
Proc Natl Acad Sci U S A
. 2008 Dec;
105(52):20888-93.
PMID: 19104050
Aminoglycoside ototoxicity has been related to a surprisingly large number of cellular structures and metabolic pathways. The finding that patients with mutations in mitochondrial rRNA are hypersusceptible to aminoglycoside-induced hearing...
3.
Hobbie S, Bruell C, Akshay S, Kalapala S, Shcherbakov D, Bottger E
Proc Natl Acad Sci U S A
. 2008 Mar;
105(9):3244-9.
PMID: 18308926
Despite the fact that important genetic diseases are caused by mutant mitochondrial ribosomes, the molecular mechanisms by which such ribosomes result in a clinical phenotype remain largely unknown. The absence...
4.
Hobbie S, Kalapala S, Akshay S, Bruell C, Schmidt S, Dabow S, et al.
Nucleic Acids Res
. 2007 Sep;
35(18):6086-93.
PMID: 17766247
Structural and genetic studies on prokaryotic ribosomes have provided important insights into fundamental aspects of protein synthesis and translational control and its interaction with ribosomal drugs. Comparable mechanistic studies in...