Sarath K Kalapala
Overview
Explore the profile of Sarath K Kalapala including associated specialties, affiliations and a list of published articles.
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5
Citations
283
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Recent Articles
1.
Rao S, Lakshminarayana S, Kondreddi R, Herve M, Camacho L, Bifani P, et al.
Sci Transl Med
. 2013 Dec;
5(214):214ra168.
PMID: 24307692
New chemotherapeutic compounds against multidrug-resistant Mycobacterium tuberculosis (Mtb) are urgently needed to combat drug resistance in tuberculosis (TB). We have identified and characterized the indolcarboxamides as a new class of...
2.
Kalapala S, Hobbie S, Bottger E, Shcherbakov D
PLoS One
. 2010 Aug;
5(8):e11960.
PMID: 20700526
Recent studies have suggested that ribosomal protein S12 modulates 16S rRNA function and susceptibility to 2-deoxystreptamine aminoglycosides. To study whether the non-restrictive K42R mutation in RpsL affects 2-deoxystreptamine susceptibility in...
3.
Hobbie S, Akshay S, Kalapala S, Bruell C, Shcherbakov D, Bottger E
Proc Natl Acad Sci U S A
. 2008 Dec;
105(52):20888-93.
PMID: 19104050
Aminoglycoside ototoxicity has been related to a surprisingly large number of cellular structures and metabolic pathways. The finding that patients with mutations in mitochondrial rRNA are hypersusceptible to aminoglycoside-induced hearing...
4.
Hobbie S, Bruell C, Akshay S, Kalapala S, Shcherbakov D, Bottger E
Proc Natl Acad Sci U S A
. 2008 Mar;
105(9):3244-9.
PMID: 18308926
Despite the fact that important genetic diseases are caused by mutant mitochondrial ribosomes, the molecular mechanisms by which such ribosomes result in a clinical phenotype remain largely unknown. The absence...
5.
Hobbie S, Kalapala S, Akshay S, Bruell C, Schmidt S, Dabow S, et al.
Nucleic Acids Res
. 2007 Sep;
35(18):6086-93.
PMID: 17766247
Structural and genetic studies on prokaryotic ribosomes have provided important insights into fundamental aspects of protein synthesis and translational control and its interaction with ribosomal drugs. Comparable mechanistic studies in...