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Stuart A C McDonald

Explore the profile of Stuart A C McDonald including associated specialties, affiliations and a list of published articles. Areas
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Articles 44
Citations 1366
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Recent Articles
1.
Ozkan A, Ingber D, Merry G, Chou D, Merry G, Posey R, et al.
Res Sq . 2025 Feb; PMID: 39975910
Inflammatory bowel disease (IBD) patients exhibit compromised intestinal barrier function and decreased mucus accumulation, as well as increased inflammation, fibrosis, and cancer risk, with symptoms often being exacerbated in women...
2.
Ozkan A, Merry G, Chou D, Posey R, Stejskalova A, Calderon K, et al.
medRxiv . 2024 Dec; PMID: 39677416
Inflammatory bowel disease (IBD) patients exhibit compromised intestinal barrier function and decreased mucus accumulation, as well as increased inflammation, fibrosis, and cancer risk, with symptoms often being exacerbated in women...
3.
Passman A, Haughey M, Carlotti E, Williams M, Cereser B, Lin M, et al.
J Hepatol . 2023 Apr; 79(2):417-432. PMID: 37088309
Background & Aims: While normal human liver is thought to be generally quiescent, clonal hepatocyte expansions have been observed, though neither their cellular source nor their expansion dynamics have been...
4.
Madan E, Palma A, Vudatha V, Trevino J, Natarajan K, Winn R, et al.
Cancer Res . 2022 Oct; 82(24):4487-4496. PMID: 36214625
The majority of human cancers evolve over time through the stepwise accumulation of somatic mutations followed by clonal selection akin to Darwinian evolution. However, the in-depth mechanisms that govern clonal...
5.
Smith A, Whitehall J, Bradshaw C, Gay D, Robertson F, Blain A, et al.
Nat Cancer . 2022 Feb; 2(1):129. PMID: 35121898
No abstract available.
6.
Evans J, Carlotti E, Lin M, Hackett R, Haughey M, Passman A, et al.
Gastroenterology . 2022 Jan; 162(4):1197-1209.e13. PMID: 34973296
Background & Aims: Barrett's esophagus (BE) is a risk factor for esophageal adenocarcinoma but our understanding of how it evolves is poorly understood. We investigated BE gland phenotype distribution, the...
7.
Schmidt M, Hackett R, Baker A, McDonald S, Quante M, Graham T
Nat Rev Gastroenterol Hepatol . 2021 Nov; 19(2):95-111. PMID: 34728819
Cancer development is a dynamic evolutionary process characterized by marked intratumoural heterogeneity at the genetic, epigenetic and phenotypic levels. Barrett oesophagus, the pre-malignant condition to oesophageal adenocarcinoma (EAC), is an...
8.
Rashid S, Freitas M, Cucchi D, Bridge G, Yao Z, Gay L, et al.
Cell Death Dis . 2019 Oct; 10(11):795. PMID: 31641109
The DNA mismatch repair (MMR) pathway is responsible for the repair of base-base mismatches and insertion/deletion loops that arise during DNA replication. MMR deficiency is currently estimated to be present...
9.
Baker A, Cereser B, Melton S, Fletcher A, Rodriguez-Justo M, Tadrous P, et al.
Cell Rep . 2019 May; 27(8):2524. PMID: 31116993
No abstract available.
10.
Baker A, Cross W, Curtius K, Al Bakir I, Choi C, Davis H, et al.
Gut . 2018 Jul; 68(6):985-995. PMID: 29991641
Objective: IBD confers an increased lifetime risk of developing colorectal cancer (CRC), and colitis-associated CRC (CA-CRC) is molecularly distinct from sporadic CRC (S-CRC). Here we have dissected the evolutionary history...