Stuart A C McDonald
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Explore the profile of Stuart A C McDonald including associated specialties, affiliations and a list of published articles.
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44
Citations
1366
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Recent Articles
11.
McDonald S, Graham T, Lavery D, Wright N, Jansen M
Cell Mol Gastroenterol Hepatol
. 2017 Mar;
1(1):41-54.
PMID: 28247864
Barrett's esophagus is characterized by the erosive replacement of esophageal squamous epithelium by a range of metaplastic glandular phenotypes. These glandular phenotypes likely change over time, and their distribution varies...
12.
Evans J, McDonald S
Adv Exp Med Biol
. 2016 Aug;
908:27-40.
PMID: 27573766
Barrett's esophagus (BO) is a preneoplastic condition described as the replacement of the stratified squamous epithelium of the distal esophagus with one that histologically presents as a diverse mixture of...
13.
Lavery D, Martinez P, Gay L, Cereser B, Novelli M, Rodriguez-Justo M, et al.
Gut
. 2015 Dec;
65(6):907-13.
PMID: 26701877
Objective: Barrett's oesophagus commonly presents as a patchwork of columnar metaplasia with and without goblet cells in the distal oesophagus. The presence of metaplastic columnar epithelium with goblet cells on...
14.
McDonald S, Lavery D, Wright N, Jansen M
Nat Rev Gastroenterol Hepatol
. 2014 Nov;
12(1):50-60.
PMID: 25365976
Barrett oesophagus develops when the lower oesophageal squamous epithelium is replaced with columnar epithelium, which shows both intestinal and gastric differentiation. No consensus has been reached on the origin of...
15.
Baker A, Cereser B, Melton S, Fletcher A, Rodriguez-Justo M, Tadrous P, et al.
Cell Rep
. 2014 Aug;
8(4):940-7.
PMID: 25127143
Human intestinal stem cell and crypt dynamics remain poorly characterized because transgenic lineage-tracing methods are impractical in humans. Here, we have circumvented this problem by quantitatively using somatic mtDNA mutations...
16.
Lavery D, Nicholson A, Poulsom R, Jeffery R, Hussain A, Gay L, et al.
Gut
. 2014 Feb;
63(12):1854-63.
PMID: 24550372
Objective: Barrett's oesophagus shows appearances described as 'intestinal metaplasia', in structures called 'crypts' but do not typically display crypt architecture. Here, we investigate their relationship to gastric glands. Methods: Cell...
17.
Pipinikas C, Kiropoulos T, Teixeira V, Brown J, Varanou A, Falzon M, et al.
Thorax
. 2014 Feb;
69(6):548-57.
PMID: 24550057
Background: Squamous cell carcinoma of the lung is a common cancer with 95% mortality at 5 years. These cancers arise from preinvasive lesions, which have a natural history of development...
18.
Jawad N, Graham T, McDonald S, Wright N
J Natl Cancer Inst
. 2014 Jan;
106(2):djt436.
PMID: 24402499
No abstract available.
19.
Zeki S, Haidry R, Graham T, Rodriguez-Justo M, Novelli M, Hoare J, et al.
Am J Gastroenterol
. 2013 Aug;
108(10):1584-92.
PMID: 23939625
Objectives: Radiofrequency ablation (RFA) is used to successfully eliminate Barrett's esophagus (BE)-related dysplasia or intramucosal carcinoma and aims to cause reversion to squamous epithelium. However, in 20% of cases RFA...
20.
Humphries A, Cereser B, Gay L, Miller D, Das B, Gutteridge A, et al.
Proc Natl Acad Sci U S A
. 2013 Jun;
110(27):E2490-9.
PMID: 23766371
The genetic and morphological development of colorectal cancer is a paradigm for tumorigenesis. However, the dynamics of clonal evolution underpinning carcinogenesis remain poorly understood. Here we identify multipotential stem cells...