Stewart D Nuttall
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Explore the profile of Stewart D Nuttall including associated specialties, affiliations and a list of published articles.
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24
Citations
373
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Recent Articles
1.
Dennis M, Newman J, Dolezal O, Hattarki M, Surjadi R, Nuttall S, et al.
Acta Crystallogr D Struct Biol
. 2020 Sep;
76(Pt 9):889-898.
PMID: 32876064
Cancer is one of the leading causes of mortality in humans, and recent work has focused on the area of immuno-oncology, in which the immune system is used to specifically...
2.
Dennis M, Morrow B, Dolezal O, Cuzzupe A, Stupple A, Newman J, et al.
Struct Dyn
. 2019 Nov;
6(6):064701.
PMID: 31768400
The WD40-repeat protein WDR5 scaffolds various epigenetic writers and is a critical component of the mammalian SET/MLL histone methyltransferase complex. Dysregulation of the MLL1 catalytic function is associated with mixed-lineage...
3.
Stanborough T, Suryadinata R, Fegan N, Powell S, Tamplin M, Nuttall S, et al.
FEMS Microbiol Lett
. 2018 Jul;
365(17).
PMID: 30052925
Gram-positive bacteria utilise class A sortases to coat the surface of their cells with a diversity of proteins that facilitate interactions with their environment and play fundamental roles in cell...
4.
Griffiths K, Dolezal O, Cao B, Nilsson S, See H, Pfleger K, et al.
J Biol Chem
. 2016 Apr;
291(24):12641-12657.
PMID: 27036939
CXCR4 is a G protein-coupled receptor with excellent potential as a therapeutic target for a range of clinical conditions, including stem cell mobilization, cancer prognosis and treatment, fibrosis therapy, and...
5.
Suryadinata R, Seabrook S, Adams T, Nuttall S, Peat T
Acta Crystallogr D Biol Crystallogr
. 2015 Jul;
71(Pt 7):1505-13.
PMID: 26143922
The assembly and anchorage of various pathogenic proteins on the surface of Gram-positive bacteria is mediated by the sortase family of enzymes. These cysteine transpeptidases catalyze a unique sorting signal...
6.
Caine J, Churches Q, Waddington L, Nigro J, Breheney K, Masters C, et al.
Biochem Biophys Res Commun
. 2014 Oct;
453(3):449-54.
PMID: 25281534
Self association of the amyloid-β (Aβ42) peptide into oligomers, high molecular weight forms, fibrils and ultimately neuritic plaques, has been correlated with progressive cognitive decline in Alzheimer's disease. Thus, insights...
7.
Baer S, Nigro J, Madej M, Nisbet R, Suryadinata R, Coia G, et al.
Org Biomol Chem
. 2014 Mar;
12(17):2675-85.
PMID: 24643508
The Sortase A (SrtA) enzyme from Staphylococcus aureus catalyses covalent attachment of protein substrates to pentaglycine cross-bridges in the Gram positive bacterial cell wall. In vitro SrtA-mediated protein ligation is...
8.
Nisbet R, Nuttall S, Robert R, Caine J, Dolezal O, Hattarki M, et al.
Proteins
. 2013 Apr;
81(10):1748-58.
PMID: 23609990
Alzheimer's disease is the most common form of dementia in humans and is related to the accumulation of the amyloid-β (Aβ) peptide and its interaction with metals (Cu, Fe, and...
9.
Nuttall S
Methods Mol Biol
. 2012 Aug;
911:27-36.
PMID: 22886244
Immunoglobulin new antigen receptors (IgNARs) from sharks are a distinct class of immune receptors, consisting of homodimers with no associated light chains. Antigen binding is encapsulated within single VNAR immunoglobulin...
10.
Madej M, Coia G, Williams C, Caine J, Pearce L, Attwood R, et al.
Biotechnol Bioeng
. 2011 Dec;
109(6):1461-70.
PMID: 22170409
Sortase-mediated protein ligation is a biological covalent conjugation system developed from the enzymatic cell wall display mechanism found in Staphylococcus aureus. This three-component system requires: (i) purified Sortase A (SrtA)...