Steven W Hardwick
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Explore the profile of Steven W Hardwick including associated specialties, affiliations and a list of published articles.
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39
Citations
1075
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Recent Articles
1.
Hooda Y, Sente A, Judy R, Smalinskaite L, Peak-Chew S, Naydenova K, et al.
bioRxiv
. 2024 Nov;
PMID: 39553992
Pentameric ligand-gated ion channels (pLGICs) are cell surface receptors of crucial importance for animal physiology. This diverse protein family mediates the ionotropic signals triggered by major neurotransmitters and includes γ-aminobutyric...
2.
Meynier V, Hardwick S, Catala M, Roske J, Oerum S, Chirgadze D, et al.
Nat Commun
. 2024 Jun;
15(1):4683.
PMID: 38824131
The human mitochondrial genome is transcribed into two RNAs, containing mRNAs, rRNAs and tRNAs, all dedicated to produce essential proteins of the respiratory chain. The precise excision of tRNAs by...
3.
Buehl C, Goff N, Mikhova M, Hardwick S, Blundell T, Modesti M, et al.
Res Sq
. 2024 Jan;
PMID: 38168382
It has been known for decades that the DNA-dependent protein kinase (DNA-PK) is only an active serine/threonine protein kinase when it is bound to a DNA double-stranded end; still, the...
4.
Kasaragod V, Malinauskas T, Wahid A, Lengyel J, Knoflach F, Hardwick S, et al.
Nat Struct Mol Biol
. 2023 Oct;
30(12):1936-1946.
PMID: 37903907
α5 subunit-containing γ-aminobutyric acid type A (GABA) receptors represent a promising drug target for neurological and neuropsychiatric disorders. Altered expression and function contributes to neurodevelopmental disorders such as Dup15q and...
5.
Kefala Stavridi A, Gontier A, Morin V, Frit P, Ropars V, Barboule N, et al.
Nucleic Acids Res
. 2023 Oct;
51(21):11732-11747.
PMID: 37870477
The classical Non-Homologous End Joining (c-NHEJ) pathway is the predominant process in mammals for repairing endogenous, accidental or programmed DNA Double-Strand Breaks. c-NHEJ is regulated by several accessory factors, post-translational...
6.
Hardwick S, Kefala Stavridi A, Chirgadze D, De Oliveira T, Charbonnier J, Ropars V, et al.
Structure
. 2023 Jun;
31(8):895-902.e3.
PMID: 37311458
The ability of humans to maintain the integrity of the genome is imperative for cellular survival. DNA double-strand breaks (DSBs) are considered the most critical type of DNA lesion, which...
7.
Seif-El-Dahan M, Kefala-Stavridi A, Frit P, Hardwick S, Chirgadze D, Maia De Oliviera T, et al.
Sci Adv
. 2023 May;
9(22):eadg2834.
PMID: 37256950
Nonhomologous end joining is a critical mechanism that repairs DNA double-strand breaks in human cells. In this work, we address the structural and functional role of the accessory protein PAXX...
8.
Buehl C, Goff N, Hardwick S, Gellert M, Blundell T, Yang W, et al.
Mol Cell
. 2023 Feb;
83(5):698-714.e4.
PMID: 36724784
Non-homologous end joining is the major double-strand break repair (DSBR) pathway in mammals. DNA-PK is the hub and organizer of multiple steps in non-homologous end joining (NHEJ). Recent high-resolution structures...
9.
Islam M, Hardwick S, Quell L, Durica-Mitic S, Chirgadze D, Gorke B, et al.
EMBO J
. 2022 Dec;
42(2):e112574.
PMID: 36504162
Biogenesis of the essential precursor of the bacterial cell envelope, glucosamine-6-phosphate (GlcN6P), is controlled by intricate post-transcriptional networks mediated by GlmZ, a small regulatory RNA (sRNA). GlmZ stimulates translation of...
10.
Saucereau Y, Wilson T, Tang M, Moncrieffe M, Hardwick S, Chirgadze D, et al.
Nat Commun
. 2022 Aug;
13(1):5110.
PMID: 36042238
Aedes aegypti has evolved to become an efficient vector for arboviruses but the mechanisms of host-pathogen tolerance are unknown. Immunoreceptor Toll and its ligand Spaetzle have undergone duplication which may...