Steven W Elmore
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Explore the profile of Steven W Elmore including associated specialties, affiliations and a list of published articles.
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38
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6077
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Recent Articles
11.
Bruncko M, Wang L, Sheppard G, Phillips D, Tahir S, Xue J, et al.
J Med Chem
. 2015 Feb;
58(5):2180-94.
PMID: 25679114
Myeloid cell leukemia 1 (MCL-1) is a BCL-2 family protein that has been implicated in the progression and survival of multiple tumor types. Herein we report a series of MCL-1...
12.
Tao Z, Hasvold L, Wang L, Wang X, Petros A, Park C, et al.
ACS Med Chem Lett
. 2014 Oct;
5(10):1088-93.
PMID: 25313317
A-1155463, a highly potent and selective BCL-XL inhibitor, was discovered through nuclear magnetic resonance (NMR) fragment screening and structure-based design. This compound is substantially more potent against BCL-XL-dependent cell lines...
13.
Koehler M, Bergeron P, Choo E, Lau K, Ndubaku C, Dudley D, et al.
ACS Med Chem Lett
. 2014 Jun;
5(6):662-7.
PMID: 24944740
Because of the promise of BCL-2 antagonists in combating chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma (NHL), interest in additional selective antagonists of antiapoptotic proteins has grown. Beginning with a...
14.
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
Souers A, Leverson J, Boghaert E, Ackler S, Catron N, Chen J, et al.
Nat Med
. 2013 Jan;
19(2):202-8.
PMID: 23291630
Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are key regulators of the apoptotic process. This family comprises proapoptotic and prosurvival proteins, and shifting the balance toward the latter...
15.
Chen J, Jin S, Abraham V, Huang X, Liu B, Mitten M, et al.
Mol Cancer Ther
. 2011 Sep;
10(12):2340-9.
PMID: 21914853
The ability of a cancer cell to avoid apoptosis is crucial to tumorigenesis and can also contribute to chemoresistance. The Bcl-2 family of prosurvival proteins (Bcl-2, Bcl-X(L), Bcl-w, Mcl-1, and...
16.
Bruncko M, Tahir S, Song X, Chen J, Ding H, Huth J, et al.
Bioorg Med Chem Lett
. 2010 Nov;
20(24):7503-6.
PMID: 21106457
We describe the development of a novel series of N-aryl-benzimidazolone HSP90 inhibitors (9) targeting the N-terminal ATP-ase site. SAR development was influenced by structure-based design based around X-ray structures of...
17.
Wilson W, OConnor O, Czuczman M, LaCasce A, Gerecitano J, Leonard J, et al.
Lancet Oncol
. 2010 Nov;
11(12):1149-59.
PMID: 21094089
Background: Proteins of the BCL-2 family regulate clonal selection and survival of lymphocytes, and are frequently overexpressed in lymphomas. Navitoclax is a targeted high-affinity small molecule that inhibits the anti-apoptotic...
18.
Petros A, Huth J, Oost T, Park C, Ding H, Wang X, et al.
Bioorg Med Chem Lett
. 2010 Sep;
20(22):6587-91.
PMID: 20870405
The Bcl-2 family of proteins plays a major role in the regulation of apoptosis, or programmed cell death. Overexpression of the anti-apoptotic members of this family (Bcl-2, Bcl-x(L), and Mcl-1)...
19.
Ackler S, Mitten M, Foster K, Oleksijew A, Refici M, Tahir S, et al.
Cancer Chemother Pharmacol
. 2010 Jan;
66(5):869-80.
PMID: 20099064
Purpose: This study was designed to test the ability of the Bcl-2 family inhibitor ABT-263 to potentiate commonly used chemotherapeutic agents and regimens in hematologic tumor models. Methods: Models of...
20.
Bardwell P, Gu J, McCarthy D, Wallace C, Bryant S, Goess C, et al.
J Immunol
. 2009 Jun;
182(12):7482-9.
PMID: 19494271
The Bcl-2 family of proteins plays a critical role in controlling immune responses by regulating the expansion and contraction of activated lymphocyte clones by apoptosis. ABT-737, which was originally developed...