Steven T Truschel
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Explore the profile of Steven T Truschel including associated specialties, affiliations and a list of published articles.
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10
Citations
641
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Recent Articles
1.
Liu C, Tate T, Batourina E, Truschel S, Potter S, Adam M, et al.
Nat Commun
. 2019 Oct;
10(1):4589.
PMID: 31597917
The urothelium is an epithelial barrier lining the bladder that protects against infection, fluid exchange and damage from toxins. The nuclear receptor Pparg promotes urothelial differentiation in vitro, and Pparg...
2.
Kullmann A, Truschel S, Wolf-Johnston A, McDonnell B, Lynn A, Kanai A, et al.
Neurourol Urodyn
. 2019 May;
38(6):1551-1559.
PMID: 31102563
Aim: To characterize the effects of acute spinal cord injury (SCI) on mitochondrial morphology and function in bladder urothelium and to test the therapeutic efficacy of early treatment with the...
3.
Truschel S, Clayton D, Beckel J, Yabes J, Yao Y, Wolf-Johnston A, et al.
PLoS One
. 2018 Jun;
13(6):e0198817.
PMID: 29883476
Lysosomal dysfunction is associated with a number of age-related pathologies that affect all organ systems. While much research has focused on neurodegenerative diseases and aging-induced changes in neurons, much less...
4.
Allosteric regulation of GRASP protein-dependent Golgi membrane tethering by mitotic phosphorylation
Truschel S, Zhang M, Bachert C, Macbeth M, Linstedt A
J Biol Chem
. 2012 Apr;
287(24):19870-5.
PMID: 22523075
Mitotic phosphorylation of the conserved GRASP domain of GRASP65 disrupts its self-association, leading to a loss of Golgi membrane tethering, cisternal unlinking, and Golgi breakdown. Recently, the structural basis of...
5.
Truschel S, Sengupta D, Foote A, Heroux A, Macbeth M, Linstedt A
J Biol Chem
. 2011 Apr;
286(23):20125-9.
PMID: 21515684
Biogenesis of the ribbon-like membrane network of the mammalian Golgi requires membrane tethering by the conserved GRASP domain in GRASP65 and GRASP55, yet the tethering mechanism is not fully understood....
6.
Truschel S, Simoes S, Setty S, Harper D, Tenza D, Thomas P, et al.
Traffic
. 2009 Jul;
10(9):1318-36.
PMID: 19624486
Melanosomes are lysosome-related organelles that coexist with lysosomes within melanocytes. The pathways by which melanosomal proteins are diverted from endocytic organelles toward melanosomes are incompletely defined. In melanocytes from mouse...
7.
Setty S, Tenza D, Truschel S, Chou E, Sviderskaya E, Theos A, et al.
Mol Biol Cell
. 2006 Dec;
18(3):768-80.
PMID: 17182842
Hermansky-Pudlak syndrome (HPS) is a genetic disorder characterized by defects in the formation and function of lysosome-related organelles such as melanosomes. HPS in humans or mice is caused by mutations...
8.
Theos A, Truschel S, Tenza D, Hurbain I, Harper D, Berson J, et al.
Dev Cell
. 2006 Mar;
10(3):343-54.
PMID: 16516837
Cargo partitioning into intralumenal vesicles (ILVs) of multivesicular endosomes underlies such cellular processes as receptor downregulation, viral budding, and biogenesis of lysosome-related organelles such as melanosomes. We show that the...
9.
Theos A, Truschel S, Raposo G, Marks M
Pigment Cell Res
. 2005 Sep;
18(5):322-36.
PMID: 16162173
Mouse coat color mutants have led to the identification of more than 120 genes that encode proteins involved in all aspects of pigmentation, from the regulation of melanocyte development and...
10.
Truschel S, Wang E, Ruiz W, Leung S, Rojas R, Lavelle J, et al.
Mol Biol Cell
. 2002 Mar;
13(3):830-46.
PMID: 11907265
The epithelium of the urinary bladder must maintain a highly impermeable barrier despite large variations in urine volume during bladder filling and voiding. To study how the epithelium accommodates these...