Adam D Linstedt
Overview
Explore the profile of Adam D Linstedt including associated specialties, affiliations and a list of published articles.
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Articles
47
Citations
1793
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0
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Recent Articles
1.
Forrester A, Rathjen S, Daniela Garcia-Castillo M, Bachert C, Couhert A, Tepshi L, et al.
Nat Chem Biol
. 2020 Feb;
16(3):327-336.
PMID: 32080624
The retrograde transport inhibitor Retro-2 has a protective effect on cells and in mice against Shiga-like toxins and ricin. Retro-2 causes toxin accumulation in early endosomes and relocalization of the...
2.
Simon E, Linstedt A
J Biol Chem
. 2018 Nov;
293(51):19866-19873.
PMID: 30389789
The surface glycoprotein (GP) of Ebola virus causes many of the virus's pathogenic effects, including a dramatic loss of endothelial cell adhesion associated with widespread hemorrhaging during infection. Although the...
3.
Venkat S, Linstedt A
Mol Biol Cell
. 2017 Aug;
28(19):2569-2578.
PMID: 28768823
Elevated, nontoxic doses of manganese (Mn) protect against Shiga toxin-1-induced cell death via down-regulation of GPP130, a cycling Golgi membrane protein that serves as an endosome-to-Golgi trafficking receptor for the...
4.
Song L, Linstedt A
Elife
. 2017 Apr;
6.
PMID: 28362263
Small molecule inhibitors of site-specific O-glycosylation by the polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-T) family are currently unavailable but hold promise as therapeutics, especially if selective against individual ppGalNAc-T isozymes. To identify a...
5.
Song L, Bachert C, Linstedt A
Methods Mol Biol
. 2016 Sep;
1496:123-31.
PMID: 27632006
Mucin-type O-glycosylation occurring in the Golgi apparatus is an important protein posttranslational modification initiated by up to 20 GalNAc-transferase isozymes with largely distinct substrate specificities. Regulation of this enzyme family...
6.
Rabouille C, Linstedt A
Front Cell Dev Biol
. 2016 Feb;
4:1.
PMID: 26858948
Originally identified as Golgi stacking factors in vitro, the Golgi reassembly stacking protein (GRASP) family has been shown to act as membrane tethers with multiple cellular roles. As an update...
7.
Tewari R, Bachert C, Linstedt A
Mol Biol Cell
. 2015 Oct;
26(24):4427-37.
PMID: 26446839
Manganese protects cells against forms of Shiga toxin by down-regulating the cycling Golgi protein GPP130. Down-regulation occurs when Mn binding causes GPP130 to oligomerize and traffic to lysosomes. To determine...
8.
Guo Y, Linstedt A
Cell Logist
. 2014 Oct;
3:e27687.
PMID: 25332841
Membrane recruitment of the COPI vesicle coat is fundamental to its function and contributes to compartment identity in the early secretory pathway. COPI recruitment is triggered by guanine nucleotide exchange...
9.
Song L, Bachert C, Schjoldager K, Clausen H, Linstedt A
J Biol Chem
. 2014 Sep;
289(44):30556-30566.
PMID: 25225288
Humans express up to 20 isoforms of GalNAc-transferase (herein T1-T20) that localize to the Golgi apparatus and initiate O-glycosylation. Regulation of this enzyme family affects a vast array of proteins...
10.
Tewari R, Jarvela T, Linstedt A
Mol Biol Cell
. 2014 Aug;
25(19):3049-58.
PMID: 25079690
Manganese (Mn) protects cells against lethal doses of purified Shiga toxin by causing the degradation of the cycling transmembrane protein GPP130, which the toxin uses as a trafficking receptor. Mn-induced...