Steven Strubbe
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Explore the profile of Steven Strubbe including associated specialties, affiliations and a list of published articles.
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9
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97
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Recent Articles
1.
Freeborn R, Strubbe S, Roncarolo M
Front Immunol
. 2022 Nov;
13:1032575.
PMID: 36389662
Type 1 regulatory T (Tr1) cells, in addition to other regulatory cells, contribute to immunological tolerance to prevent autoimmunity and excessive inflammation. Tr1 cells arise in the periphery upon antigen...
2.
Lambrechts N, Liang K, Velghe I, Strubbe S, Dolens A, Taghon T
Methods Mol Biol
. 2022 Nov;
2580:335-354.
PMID: 36374468
Not only is human T cell development characterized by unique changes in surface marker expression, but it also requires specific growth factors and conditions to mimic and study T cell...
3.
Roels J, Van Hulle J, Lavaert M, Kuchmiy A, Strubbe S, Putteman T, et al.
Front Immunol
. 2022 Aug;
13:960918.
PMID: 35967340
T cells are generated from hematopoietic stem cells through a highly organized developmental process, in which stage-specific molecular events drive maturation towards αβ and γδ T cells. Although many of...
4.
Modeling of human T cell development in vitro as a read-out for hematopoietic stem cell multipotency
Strubbe S, Taghon T
Biochem Soc Trans
. 2021 Oct;
49(5):2113-2122.
PMID: 34643218
Hematopoietic stem cells (HSCs) reside in distinct sites throughout fetal and adult life and give rise to all cells of the hematopoietic system. Because of their multipotency, HSCs are capable...
5.
Strubbe S, De Bruyne M, Pannicke U, Beyls E, Vandekerckhove B, Leclercq G, et al.
Front Immunol
. 2021 Jul;
12:674226.
PMID: 34220820
Severe Combined Immune Deficiency (SCID) is a primary deficiency of the immune system in which opportunistic and recurring infections are often fatal during neonatal or infant life. SCID is caused...
6.
Tottone L, Lancho O, Loh J, Singh A, Kimura S, Roels J, et al.
Blood Cancer Discov
. 2021 Jan;
2(1):92-109.
PMID: 33458694
Long-range oncogenic enhancers play an important role in cancer. Yet, whether similar regulation of tumor suppressor genes is relevant remains unclear. Loss of expression of PTEN is associated with the...
7.
Loontiens S, Dolens A, Strubbe S, Van de Walle I, Moore F, Depestel L, et al.
Front Cell Dev Biol
. 2020 Nov;
8:599472.
PMID: 33251223
Transcriptional control of hematopoiesis involves complex regulatory networks and functional perturbations in one of these components often results in malignancies. Loss-of-function mutations in , encoding a presumed epigenetic regulator, have...
8.
Roels J, Thenoz M, Szarzynska B, Landfors M, De Coninck S, Demoen L, et al.
Blood Cancer Discov
. 2020 Nov;
1(3):274-289.
PMID: 33179015
Cancer cells display DNA hypermethylation at specific CpG islands in comparison to their normal healthy counterparts, but the mechanism that drives this so-called CpG island methylator phenotype (CIMP) remains poorly...
9.
Roels J, Kuchmiy A, De Decker M, Strubbe S, Lavaert M, Liang K, et al.
Nat Immunol
. 2020 Jul;
21(10):1280-1292.
PMID: 32719521
The development of TCRαβ and TCRγδ T cells comprises a step-wise process in which regulatory events control differentiation and lineage outcome. To clarify these mechanisms, we employed RNA-sequencing, ATAC-sequencing and...