Steven Raynard
Overview
Explore the profile of Steven Raynard including associated specialties, affiliations and a list of published articles.
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10
Citations
746
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Recent Articles
1.
Xue X, Raynard S, Busygina V, Singh A, Sung P
J Biol Chem
. 2013 Apr;
288(20):14221-14227.
PMID: 23543748
The conserved BTR complex, composed of the Bloom's syndrome helicase (BLM), topoisomerase IIIα, RMI1, and RMI2, regulates homologous recombination in favor of non-crossover formation via the dissolution of the double...
2.
Schwendener S, Raynard S, Paliwal S, Cheng A, Kanagaraj R, Shevelev I, et al.
J Biol Chem
. 2010 Mar;
285(21):15739-45.
PMID: 20348101
Homologous recombination (HR) provides an efficient mechanism for error-free repair of DNA double-strand breaks (DSBs). However, HR can be also harmful as inappropriate or untimely HR events can give rise...
3.
Raynard S, Sung P
Cold Spring Harb Protoc
. 2010 Feb;
2009(1):pdb.prot5120.
PMID: 20147015
Homologous recombination is an important mechanism for the repair of damaged chromosomes, for preventing the demise of damaged replication forks, and for several other aspects of chromosome metabolism and maintenance....
4.
Niu H, Raynard S, Sung P
Genes Dev
. 2009 Jul;
23(13):1481-6.
PMID: 19571177
DNA end resection is critical for chromosome break repair by homologous recombination and influences the efficiency of repair by nonhomologous DNA end joining. An elegant study by Sinha and colleagues...
5.
Raynard S, Niu H, Sung P
Genes Dev
. 2008 Nov;
22(21):2903-7.
PMID: 18981468
Nucleolytic processing of DNA double-strand breaks (DSBs) generates 3' ssDNA tails that are essential for the assembly of DNA damage checkpoint signaling and DNA repair protein complexes. Genetic studies have...
6.
Singh T, Ali A, Busygina V, Raynard S, Fan Q, Du C, et al.
Genes Dev
. 2008 Oct;
22(20):2856-68.
PMID: 18923083
Bloom Syndrome is an autosomal recessive cancer-prone disorder caused by mutations in the BLM gene. BLM encodes a DNA helicase of the RECQ family, and associates with Topo IIIalpha and...
7.
Raynard S, Zhao W, Bussen W, Lu L, Ding Y, Busygina V, et al.
J Biol Chem
. 2008 Apr;
283(23):15701-8.
PMID: 18390547
The BLAP75 protein combines with the BLM helicase and topoisomerase (Topo) IIIalpha to form an evolutionarily conserved complex, termed the BTB complex, that functions to regulate homologous recombination. BLAP75 binds...
8.
Hu Y, Raynard S, Sehorn M, Lu X, Bussen W, Zheng L, et al.
Genes Dev
. 2007 Nov;
21(23):3073-84.
PMID: 18003859
Members of the RecQ helicase family play critical roles in genome maintenance. There are five RecQ homologs in mammals, and defects in three of these (BLM, WRN, and RECQL4) give...
9.
Bussen W, Raynard S, Busygina V, Singh A, Sung P
J Biol Chem
. 2007 Aug;
282(43):31484-92.
PMID: 17728255
BLM, the protein mutated in Bloom's syndrome, possesses a helicase activity that can dissociate DNA structures, including the Holliday junction, expected to arise during homologous recombination. BLM is stably associated...
10.
Raynard S, Bussen W, Sung P
J Biol Chem
. 2006 Apr;
281(20):13861-4.
PMID: 16595695
Bloom syndrome (BS), an autosomal recessive disorder, is marked by a high incidence of cancer early in life. Cells derived from BS patients are unstable genetically and exhibit frequent sister...