Steven R LaPlante
Overview
Explore the profile of Steven R LaPlante including associated specialties, affiliations and a list of published articles.
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Articles
57
Citations
800
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0
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Recent Articles
1.
Boulon R, Mazeaud C, Farahani M, Broquiere M, Iddir M, Charpentier T, et al.
ACS Pharmacol Transl Sci
. 2024 Dec;
7(12):4043-4055.
PMID: 39698276
Drug repurposing can serve an important role in rapidly discovering medicament options for emerging microbial pandemics. In this study, a pragmatic approach is demonstrated for screening and testing drug combinations...
2.
Mistretta M, Cimino M, Campagne P, Volant S, Kornobis E, Hebert O, et al.
Nat Commun
. 2024 May;
15(1):4175.
PMID: 38755132
Drug-recalcitrant infections are a leading global-health concern. Bacterial cells benefit from phenotypic variation, which can suggest effective antimicrobial strategies. However, probing phenotypic variation entails spatiotemporal analysis of individual cells that...
3.
Franca T, Saidi F, Ajamian A, Islam S, LaPlante S
ACS Omega
. 2024 Mar;
9(11):13217-13226.
PMID: 38524450
Recent advances in iterative neural network analyses (e.g., AlphaFold2 and RoseTTA fold) have been revolutionary for protein 3D structure prediction, especially for difficult-to-manipulate α-helical/β-barrel integral membrane proteins. These model structures...
4.
Botelho F, Franca T, LaPlante S
Mini Rev Med Chem
. 2024 Feb;
24(12):1148-1161.
PMID: 38350844
The castor plant (Ricinus communis) is primarily known for its seeds, which contain a unique fatty acid called ricinoleic acid with several industrial and commercial applications. Castor seeds also contain...
5.
LaPlante S, Coric P, Bouaziz S, Franca T
Microbes Infect
. 2024 Jan;
26(7):105297.
PMID: 38199267
Small molecule drugs have an important role to play in combating viral infections, and biophysics support has been central for contributing to the discovery and design of direct acting antivirals....
6.
Fnaiche A, Melin L, Gonzalez Suarez N, Paquin A, Vu V, Li F, et al.
Bioorg Med Chem Lett
. 2023 Sep;
95:129488.
PMID: 37770003
The Hippo pathway regulates organ size and tissue homeostasis by controlling cell proliferation and apoptosis. The YAP-TEAD transcription factor, the downstream effector of the Hippo pathway, regulates the expression of...
7.
Larda S, Ayotte Y, Denk M, Coote P, Heffron G, Bendahan D, et al.
J Med Chem
. 2023 Sep;
66(19):13416-13427.
PMID: 37732695
Establishing robust structure-activity relationships (SARs) is key to successful drug discovery campaigns, yet it often remains elusive due to screening and hit validation artifacts (false positives and false negatives), which...
8.
Franca T, da Silva Goncalves A, Berube C, Voyer N, Aubry N, LaPlante S
ACS Omega
. 2023 Jul;
8(29):25832-25838.
PMID: 37521620
Macrocyclic peptidomimetics have been seriously contributing to our arsenal of drugs to combat diseases. The search for nature's discoveries led us to mortiamides A-D (found in a novel fungus from...
9.
Ali Z, Cardoza J, Basak S, Narsaria U, Bhattacharjee S, G U, et al.
Appl Biochem Biotechnol
. 2023 Jul;
196(4):2137-2160.
PMID: 37479961
Bolivian hemorrhagic fever (BHF) caused by Machupo virus (MACV) is a New World arenavirus having a reported mortality rate of 25-35%. The BHF starts with fever, followed by headache, and...
10.
Vieira L, Almeida J, de Koning M, LaPlante S, Borges Jr I, Franca T
Chem Biol Interact
. 2023 Jul;
382:110622.
PMID: 37442286
The A-series is the most recent generation of chemical warfare nerve agents (CWA) which act directly on the inhibition of the human acetylcholinesterase (HssAChE) enzyme. These compounds lack accurate experimental...