Steven P Kleopoulos
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Explore the profile of Steven P Kleopoulos including associated specialties, affiliations and a list of published articles.
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12
Citations
110
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Recent Articles
1.
Humphrey J, Brophy E, Kosoy R, Zeng B, Coccia E, Mattei D, et al.
Nat Genet
. 2025 Mar;
57(3):604-615.
PMID: 40033057
Microglia, the innate immune cells of the central nervous system, have been genetically implicated in multiple neurodegenerative diseases. Mapping the genetics of gene expression in human microglia has identified several...
2.
Lee D, Vicari J, Porras C, Spencer C, Pjanic M, Wang X, et al.
medRxiv
. 2024 Dec;
PMID: 39677435
The complex roles of myeloid cells, including microglia and perivascular macrophages, are central to the neurobiology of Alzheimer's disease (AD), yet they remain incompletely understood. Here, we profiled 832,505 human...
3.
Nwaneshiudu C, Girdhar K, Kleopoulos S, Fullard J, Butelman E, Parvaz M, et al.
bioRxiv
. 2024 Jul;
PMID: 39026764
Background-: Individuals with cocaine use disorder (CUD) who attempt abstinence experience craving and relapse, which poses challenges in treatment. Longitudinal studies linking behavioral manifestations in CUD to the blood transcriptome...
4.
Zeng B, Bendl J, Deng C, Lee D, Misir R, Reach S, et al.
Science
. 2024 May;
384(6698):eadh4265.
PMID: 38781378
Nucleotide variants in cell type-specific gene regulatory elements in the human brain are risk factors for human disease. We measured chromatin accessibility in 1932 aliquots of sorted neurons and non-neurons...
5.
Humphrey J, Brophy E, Kosoy R, Zeng B, Coccia E, Mattei D, et al.
medRxiv
. 2023 Dec;
PMID: 38076956
Microglia, the innate immune cells of the central nervous system, have been genetically implicated in multiple neurodegenerative diseases. We previously mapped the genetic regulation of gene expression and mRNA splicing...
6.
Girdhar K, Bendl J, Baumgartner A, Therrien K, Venkatesh S, Mathur D, et al.
Res Sq
. 2023 Oct;
PMID: 37886514
Non-coding variants increase risk of neuropsychiatric disease. However, our understanding of the cell-type specific role of the non-coding genome in disease is incomplete. We performed population scale (N=1,393) chromatin accessibility...
7.
Girdhar K, Bendl J, Baumgartner A, Therrien K, Venkatesh S, Mathur D, et al.
medRxiv
. 2023 Oct;
PMID: 37873320
Non-coding variants increase risk of neuropsychiatric disease. However, our understanding of the cell-type specific role of the non-coding genome in disease is incomplete. We performed population scale (N=1,393) chromatin accessibility...
8.
Rahman S, Dong P, Apontes P, Fernando M, Kosoy R, Townsley K, et al.
Nucleic Acids Res
. 2023 Oct;
51(20):11142-11161.
PMID: 37811875
The human brain is a complex organ comprised of distinct cell types, and the contribution of the 3D genome to lineage specific gene expression remains poorly understood. To decipher cell...
9.
Zeng B, Bendl J, Deng C, Lee D, Misir R, Reach S, et al.
bioRxiv
. 2023 Apr;
PMID: 37090548
Nucleotide variants in cell type-specific gene regulatory elements in the human brain are major risk factors of human disease. We measured chromatin accessibility in sorted neurons and glia from 1,932...
10.
Bendl J, Hauberg M, Girdhar K, Im E, Vicari J, Rahman S, et al.
Nat Neurosci
. 2022 Sep;
25(10):1366-1378.
PMID: 36171428
To characterize the dysregulation of chromatin accessibility in Alzheimer's disease (AD), we generated 636 ATAC-seq libraries from neuronal and nonneuronal nuclei isolated from the superior temporal gyrus and entorhinal cortex...