Steven O Smith
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Explore the profile of Steven O Smith including associated specialties, affiliations and a list of published articles.
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102
Citations
3082
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Recent Articles
1.
Irizarry B, Davis J, Rajpoot J, Zhu X, Xu F, Smith S, et al.
Biochemistry
. 2025 Jan;
64(5):1065-1078.
PMID: 39763333
Cerebral vascular deposition of the amyloid-β (Aβ) peptide, a condition known as cerebral amyloid angiopathy (CAA), is associated with intracerebral hemorrhaging and contributes to disease progression in Alzheimer's disease (AD)...
2.
Xu F, Fu Z, Dass S, Kotarba A, Davis J, Smith S, et al.
Nat Commun
. 2024 Jul;
15(1):6089.
PMID: 39030165
No abstract available.
3.
Fu Z, Crooks E, Irizarry B, Zhu X, Chowdhury S, Van Nostrand W, et al.
J Struct Biol
. 2024 Apr;
216(2):108092.
PMID: 38615725
Cerebral amyloid angiopathy (CAA) is associated with the accumulation of fibrillar Aβ peptides upon and within the cerebral vasculature, which leads to loss of vascular integrity and contributes to disease...
4.
Defour J, Leroy E, Dass S, Balligand T, Levy G, Brett I, et al.
Elife
. 2023 Jun;
12.
PMID: 37338955
Dimerization of the thrombopoietin receptor (TpoR) is necessary for receptor activation and downstream signaling through activated Janus kinase 2. We have shown previously that different orientations of the transmembrane (TM)...
5.
Smith S
Annu Rev Biophys
. 2023 May;
52:301-317.
PMID: 37159291
Rhodopsin is the photoreceptor in human rod cells responsible for dim-light vision. The visual receptors are part of the large superfamily of G protein-coupled receptors (GPCRs) that mediate signal transduction...
6.
Zhu X, Schrader J, Irizarry B, Smith S, Van Nostrand W
Biomedicines
. 2022 Nov;
10(11).
PMID: 36428550
Fibrillar amyloid β-protein (Aβ) deposits in the brain, which are primarily composed of Aβ40 or Aβ42 peptides, are key pathological features of Alzheimer's disease (AD) and related disorders. Although the...
7.
Rajpoot J, Crooks E, Irizarry B, Amundson A, Van Nostrand W, Smith S
Biochemistry
. 2022 Jun;
61(12):1181-1198.
PMID: 35666749
Two distinct diseases are associated with the deposition of fibrillar amyloid-β (Aβ) peptides in the human brain in an age-dependent fashion. Alzheimer's disease is primarily associated with parenchymal plaque deposition...
8.
Chandler B, Todd L, Smith S
Prog Nucl Magn Reson Spectrosc
. 2022 Mar;
128:25-43.
PMID: 35282868
G protein-coupled receptors (GPCRs) have a simple seven transmembrane helix architecture which has evolved to recognize a diverse number of chemical signals. The more than 800 GPCRs encoded in the...
9.
Irizarry B, Davis J, Zhu X, Boon B, Rozemuller A, Van Nostrand W, et al.
J Biol Chem
. 2021 Oct;
297(5):101259.
PMID: 34599967
The accumulation of fibrillar amyloid-β (Aβ) peptides alongside or within the cerebral vasculature is the hallmark of cerebral amyloid angiopathy (CAA). This condition commonly co-occurs with Alzheimer's disease (AD) and...
10.
Smith S
Trends Biochem Sci
. 2021 Sep;
46(12):1017-1029.
PMID: 34538727
Class A G protein-coupled receptors have evolved to recognize ligands ranging from small-molecule odorants to proteins. Although they are among the most diverse membrane receptors in eukaryotic organisms, they possess...