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Evan Crocker

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Articles 12
Citations 384
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Recent Articles
1.
Ahuja S, Crocker E, Eilers M, Hornak V, Hirshfeld A, Ziliox M, et al.
J Biol Chem . 2009 Jan; 284(15):10190-201. PMID: 19176531
Rhodopsin is a highly specialized G protein-coupled receptor (GPCR) that is activated by the rapid photochemical isomerization of its covalently bound 11-cis-retinal chromophore. Using two-dimensional solid-state NMR spectroscopy, we defined...
2.
Crocker E, Eilers M, Ahuja S, Hornak V, Hirshfeld A, Sheves M, et al.
J Mol Biol . 2006 Jan; 357(1):163-72. PMID: 16414074
Isomerization of the 11-cis retinal chromophore in the visual pigment rhodopsin is coupled to motion of transmembrane helix H6 and receptor activation. We present solid-state magic angle spinning NMR measurements...
3.
Anderson L, Marshall G, Crocker E, Smith S, Baranski T
J Biol Chem . 2005 Jun; 280(35):31019-26. PMID: 15983037
The carboxyl terminus of the G protein alpha subunit plays a key role in interactions with G protein-coupled receptors. Previous studies that have incorporated covalently attached probes have demonstrated that...
4.
Liu W, Crocker E, Constantinescu S, Smith S
Biophys J . 2005 May; 89(2):1194-202. PMID: 15894629
gp55-P is a dimeric membrane protein with a single transmembrane helix that is coded by the env gene of the polycythemic strain of the spleen focus forming virus. gp55-P activates...
5.
Patel A, Crocker E, Reeves P, Getmanova E, Eilers M, Khorana H, et al.
J Mol Biol . 2005 Mar; 347(4):803-12. PMID: 15769471
Hydrogen bonding interactions between transmembrane helices stabilize the visual pigment rhodopsin in an inactive conformation in the dark. The crystal structure of rhodopsin has previously revealed that Glu122 and Trp126...
6.
Howard K, Liu W, Crocker E, Nanda V, Lear J, DeGrado W, et al.
Protein Sci . 2005 Mar; 14(4):1019-24. PMID: 15741331
A peptide designed to form a homo-oligomeric transmembrane helical bundle was reconstituted into lipid bilayers and studied by using (2)H NMR (nuclear magnetic resonance) with magic angle spinning to confirm...
7.
Liu W, Crocker E, Zhang W, Elliott J, Luy B, Li H, et al.
Biochemistry . 2005 Mar; 44(9):3591-7. PMID: 15736968
Amyloid fibrils associated with diseases such as Alzheimer's are often derived from the transmembrane helices of membrane proteins. It is known that the fibrils have a cross-beta-sheet structure where main...
8.
Patel A, Crocker E, Eilers M, Hirshfeld A, Sheves M, Smith S
Proc Natl Acad Sci U S A . 2004 Jun; 101(27):10048-53. PMID: 15220479
Activation of the visual pigment rhodopsin is caused by 11-cis to -trans isomerization of its retinal chromophore. High-resolution solid-state NMR measurements on both rhodopsin and the metarhodopsin II intermediate show...
9.
Crocker E, Patel A, Eilers M, Jayaraman S, Getmanova E, Reeves P, et al.
J Biomol NMR . 2004 Mar; 29(1):11-20. PMID: 15017136
Two dimensional (2D) solid-state (13)C.(13)C dipolar recoupling experiments are performed on a series of model compounds and on the visual pigment rhodopsin to establish the most effective method for long...
10.
Zhang W, Crocker E, McLaughlin S, Smith S
J Biol Chem . 2003 Apr; 278(24):21459-66. PMID: 12670959
Electrostatic interactions with positively charged regions of membrane-associated proteins such as myristoylated alanine-rich C kinase substrate (MARCKS) may have a role in regulating the level of free phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)...