Steven M Rubenstein
Overview
Explore the profile of Steven M Rubenstein including associated specialties, affiliations and a list of published articles.
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Articles
3
Citations
47
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0
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Recent Articles
1.
Fox B, Sugimoto K, Iio K, Yoshida A, Zhang J, Li K, et al.
J Med Chem
. 2014 Mar;
57(8):3464-83.
PMID: 24670009
The discovery and optimization of a series of acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors based on a pyrimido[4,5-b][1,4]oxazine scaffold is described. The SAR of a moderately potent HTS hit was...
2.
Li K, McGee L, Fisher B, Sudom A, Liu J, Rubenstein S, et al.
Bioorg Med Chem Lett
. 2013 Feb;
23(5):1238-44.
PMID: 23374866
The discovery, structure-based design, synthesis, and optimization of NIK inhibitors are described. Our work began with an HTS hit, imidazopyridinyl pyrimidinamine 1. We utilized homology modeling and conformational analysis to...
3.
Taygerly J, McGee L, Rubenstein S, Houze J, Cushing T, Li Y, et al.
Bioorg Med Chem
. 2013 Jan;
21(4):979-92.
PMID: 23294830
PPARγ is a member of the nuclear hormone receptor family and plays a key role in the regulation of glucose homeostasis. This Letter describes the discovery of a novel chemical...