Steven M Jay
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Explore the profile of Steven M Jay including associated specialties, affiliations and a list of published articles.
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70
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Recent Articles
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2.
Park C, Lei Z, Li Y, Ren B, He J, Huang H, et al.
J Neuroinflammation
. 2024 Oct;
21(1):252.
PMID: 39375720
Background: Neuroinflammation reportedly plays a critical role in the pathogenesis of sepsis-associated encephalopathy (SAE). We previously reported that circulating plasma extracellular vesicles (EVs) from septic mice are proinflammatory. In the...
3.
Pottash A, Levy D, Powsner E, Pirolli N, Kuo L, Solomon T, et al.
ACS Biomater Sci Eng
. 2024 Sep;
10(10):6286-6298.
PMID: 39305230
Extracellular vesicles (EVs) are physiological vectors for the intercellular transport of a variety of molecules. Among these, small RNAs, and especially microRNAs (miRNAs), have been identified as prevalent components, and...
4.
Pirolli N, Reus L, Jay S
Methods Mol Biol
. 2024 Aug;
2843:155-162.
PMID: 39141299
Bacterial extracellular vesicles (BEVs) have extraordinary biotechnological potential, but traditional purification methods lack desirable scalability and commonly co-isolate protein impurities, limiting clinical translation. Anion exchange chromatography (AEC) separates molecules based...
5.
Pirolli N, Jay S
Methods Mol Biol
. 2024 Aug;
2843:15-23.
PMID: 39141291
Bacterial extracellular vesicles (BEVs) have emerged as mediators of transkingdom communication with numerous potential biotechnological applications. As such, investigation of BEV's protein composition holds promise to uncover new biological mechanisms,...
6.
Levy D, Solomon T, Jay S
Curr Opin Biotechnol
. 2024 Jan;
85:103067.
PMID: 38277970
Extracellular vesicles (EVs) are an emergent next-generation biotechnology with broad application potential. In particular, immunomodulatory bioactivity of EVs leading to anti-inflammatory effects is well-characterized. Cell source and culture conditions are...
7.
Born L, Bengali S, Hsu A, Nourmohammadi Abadchi S, Chang K, Lay F, et al.
Int J Mol Sci
. 2023 Sep;
24(18).
PMID: 37762397
Wound therapies involving gene delivery to the skin have significant potential due to the advantage and ease of local treatment. However, choosing the appropriate vector to enable successful gene expression...
8.
Pirolli N, Reus L, Mamczarz Z, Khan S, Bentley W, Jay S
Biotechnol Bioeng
. 2023 Aug;
120(11):3368-3380.
PMID: 37555379
Bacterial extracellular vesicles (BEVs), including outer membrane vesicles, have emerged as a promising new class of vaccines and therapeutics to treat cancer and inflammatory diseases, among other applications. However, clinical...
9.
Dutta D, Pirolli N, Levy D, Tsao J, Seecharan N, Wang Z, et al.
Biomater Sci
. 2023 Jun;
11(16):5474-5489.
PMID: 37367824
Extracellular vesicles (EVs) derived from neural progenitor/stem cells (NPSCs) have shown promising efficacy in a variety of preclinical models. However, NPSCs lack critical neuroregenerative functionality such as myelinating capacity. Further,...
10.
Levy D, Nourmohammadi Abadchi S, Shababi N, Ravari M, Pirolli N, Bergeron C, et al.
Adv Healthc Mater
. 2023 Jun;
12(26):e2300879.
PMID: 37335811
Extracellular vesicles (EVs) derived from mesenchymal stem/stromal cells (MSCs) have recently been explored in clinical trials for treatment of diseases with complex pathophysiologies. However, production of MSC EVs is currently...