Steven L Spitalnik
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Explore the profile of Steven L Spitalnik including associated specialties, affiliations and a list of published articles.
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128
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3078
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Recent Articles
1.
Peltier S, Marin M, Dzieciatkowska M, Dussiot M, Roy M, Bruce J, et al.
J Clin Invest
. 2025 Mar;
PMID: 40067362
Although refrigerated storage slows the metabolism of volunteer donor RBCs, which is essential in transfusion medicine, cellular aging still occurs throughout this in vitro process. Storage-induced microerythrocytes (SMEs) are morphologically-altered...
2.
Roh D, Liu M, Strobino K, Assuras S, Guzman V, Levin B, et al.
Front Aging Neurosci
. 2025 Mar;
17:1543798.
PMID: 40026420
Objective: Red blood cell (RBC) concentration impacts cerebrovascular disease, yet it is unclear whether RBC concentrations relate to dementia risk, particularly in racially/ethnically diverse cohorts. We investigated whether RBC concentrations...
3.
DAlessandro A, Keele G, Hay A, Hay A, Nemkov T, Earley E, et al.
Blood
. 2024 Nov;
145(7):765-783.
PMID: 39541586
Red blood cell (RBC) metabolism regulates hemolysis during aging in vivo and in the blood bank. However, the genetic underpinnings of RBC metabolic heterogeneity and extravascular hemolysis at population scale...
4.
Reisz J, Earley E, Nemkov T, Key A, Stephenson D, Keele G, et al.
Aging Cell
. 2024 Oct;
24(2):e14388.
PMID: 39478346
Increasing global life expectancy motivates investigations of molecular mechanisms of aging and age-related diseases. This study examines age-associated changes in red blood cells (RBCs), the most numerous host cell in...
5.
Peltier S, Marin M, Dzieciatkowska M, Dussiot M, Roy M, Bruce J, et al.
bioRxiv
. 2024 Sep;
PMID: 39314353
Although refrigerated storage slows the metabolism of volunteer donor RBCs, cellular aging still occurs throughout this process, which is essential in transfusion medicine. Storage-induced microerythrocytes (SMEs) are morphologically-altered senescent RBCs...
6.
Ding J, Montemayor-Garcia C, Stotler B, Spitalnik S, Ayala Mendez J
Blood Transfus
. 2024 Aug;
PMID: 39133627
Background: Rh disease occurs following maternal alloimmunization, which can develop due to RhD blood group antigen incompatibility between a mother and her fetus. Despite developing robust clinical protocols for effective...
7.
Nemkov T, Stephenson D, Earley E, Keele G, Hay A, Key A, et al.
Cell Metab
. 2024 Jul;
36(9):1979-1997.e13.
PMID: 38964323
Mature red blood cells (RBCs) lack mitochondria and thus exclusively rely on glycolysis to generate adenosine triphosphate (ATP) during aging in vivo or storage in blood banks. Here, we leveraged...
8.
Thomas T, Francis R, Zimring J, Kao J, Nemkov T, Spitalnik S
Antioxidants (Basel)
. 2024 Jun;
13(6).
PMID: 38929156
Oxidative stress can damage tissues and cells, and their resilience or susceptibility depends on the robustness of their antioxidant mechanisms. The latter include small molecules, proteins, and enzymes, which are...
9.
DAlessandro A, Keele G, Hay A, Nemkov T, Earley E, Stephenson D, et al.
bioRxiv
. 2024 Jun;
PMID: 38915523
Highlights: Steap3 regulates lipid peroxidation and extravascular hemolysis in 350 diversity outbred miceSteap3 SNPs are linked to RBC iron, hemolysis, vesiculation in 13,091 blood donorsmQTL analyses of oxylipins identified ferroptosis-related...
10.
Nemkov T, Key A, Stephenson D, Earley E, Keele G, Hay A, et al.
Blood
. 2024 Mar;
143(24):2517-2533.
PMID: 38513237
Recent large-scale multiomics studies suggest that genetic factors influence the chemical individuality of donated blood. To examine this concept, we performed metabolomics analyses of 643 blood units from volunteers who...