Steven K Higginbottom
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Explore the profile of Steven K Higginbottom including associated specialties, affiliations and a list of published articles.
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22
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3018
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Recent Articles
1.
Culver R, Spencer S, Violette A, Lemus Silva E, Takeuchi T, Nafarzadegan C, et al.
bioRxiv
. 2024 May;
PMID: 38712253
Our understanding of region-specific microbial function within the gut is limited due to reliance on stool. Using a recently developed capsule device, we exploit regional sampling from the human intestines...
2.
Gellman R, Olm M, Terrapon N, Enam F, Higginbottom S, Sonnenburg J, et al.
Cell Rep
. 2024 Mar;
42(11.
PMID: 38510311
Industrialization has transformed the gut microbiota, reducing the prevalence of relative to . Here, we isolate and strains from the microbiota of Hadza hunter-gatherers in Tanzania, a population with high...
3.
Gerrick E, Zlitni S, West P, Carter M, Mechler C, Olm M, et al.
Cell
. 2023 Dec;
187(1):62-78.e20.
PMID: 38096822
The microbiota influences intestinal health and physiology, yet the contributions of commensal protists to the gut environment have been largely overlooked. Here, we discover human- and rodent-associated parabasalid protists, revealing...
4.
Gellman R, Olm M, Terrapon N, Enam F, Higginbottom S, Sonnenburg J, et al.
bioRxiv
. 2023 Mar;
PMID: 36945614
Industrialization has transformed the gut microbiota, reducing the prevalence of relative to . Here, we isolate and strains from the microbiota of Hadza hunter-gatherers of Tanzania, a population with high...
5.
Pruss K, Chen H, Liu Y, Van Treuren W, Higginbottom S, Jarman J, et al.
Nat Commun
. 2023 Jan;
14(1):512.
PMID: 36720857
The human gut microbiota produces dozens of small molecules that circulate in blood, accumulate to comparable levels as pharmaceutical drugs, and influence host physiology. Despite the importance of these metabolites...
6.
Pensinger D, Fisher A, Dobrila H, Van Treuren W, Gardner J, Higginbottom S, et al.
Infect Immun
. 2023 Jan;
91(2):e0057022.
PMID: 36692308
A disrupted "dysbiotic" gut microbiome engenders susceptibility to the diarrheal pathogen Clostridioides difficile by impacting the metabolic milieu of the gut. Diet, in particular the microbiota-accessible carbohydrates (MACs) found in...
7.
Liu Y, Chen H, Van Treuren W, Hou B, Higginbottom S, Dodd D
Nat Microbiol
. 2022 May;
7(5):695-706.
PMID: 35505245
Gut bacteria face a key problem in how they capture enough energy to sustain their growth and physiology. The gut bacterium Clostridium sporogenes obtains its energy by utilizing amino acids...
8.
Aranda-Diaz A, Ng K, Thomsen T, Real-Ramirez I, Dahan D, Dittmar S, et al.
Cell Host Microbe
. 2022 Jan;
30(2):260-272.e5.
PMID: 35051349
Efforts to probe the role of the gut microbiota in disease would benefit from a system in which patient-derived bacterial communities can be studied at scale. We addressed this by...
9.
Pruss K, Enam F, Battaglioli E, DeFeo M, Diaz O, Higginbottom S, et al.
Nat Metab
. 2022 Jan;
4(1):19-28.
PMID: 34992297
The enteric pathogen Clostridioides difficile (Cd) is responsible for a toxin-mediated infection that causes more than 200,000 recorded hospitalizations and 13,000 deaths in the United States every year. However, Cd...
10.
Vasquez K, Willis L, Cira N, Ng K, Pedro M, Aranda-Diaz A, et al.
Cell Host Microbe
. 2021 Sep;
29(9):1454-1468.e4.
PMID: 34473943
Due to limitations on high-resolution strain tracking, selection dynamics during gut microbiota colonization and transmission between hosts remain mostly mysterious. Here, we introduced hundreds of barcoded Escherichia coli strains into...