Curt R Fischer
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Explore the profile of Curt R Fischer including associated specialties, affiliations and a list of published articles.
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36
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1055
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Recent Articles
1.
Pruss K, Chen H, Liu Y, Van Treuren W, Higginbottom S, Jarman J, et al.
Nat Commun
. 2023 Jan;
14(1):512.
PMID: 36720857
The human gut microbiota produces dozens of small molecules that circulate in blood, accumulate to comparable levels as pharmaceutical drugs, and influence host physiology. Despite the importance of these metabolites...
2.
Pruss K, Enam F, Battaglioli E, DeFeo M, Diaz O, Higginbottom S, et al.
Nat Metab
. 2022 Jan;
4(1):19-28.
PMID: 34992297
The enteric pathogen Clostridioides difficile (Cd) is responsible for a toxin-mediated infection that causes more than 200,000 recorded hospitalizations and 13,000 deaths in the United States every year. However, Cd...
3.
Wawro A, Gajera C, Baker S, Lesniak R, Montine K, Fischer C, et al.
J Neurochem
. 2021 Jul;
158(5):1074-1082.
PMID: 34273193
Imbalance in the metabolic pathway linking excitatory and inhibitory neurotransmission has been implicated in multiple psychiatric and neurologic disorders. Recently, we described enantiomer-specific effects of 2-methylglutamate, which is not decarboxylated...
4.
Han S, Van Treuren W, Fischer C, Merrill B, DeFelice B, Sanchez J, et al.
Nature
. 2021 Jul;
595(7867):415-420.
PMID: 34262212
Gut microorganisms modulate host phenotypes and are associated with numerous health effects in humans, ranging from host responses to cancer immunotherapy to metabolic disease and obesity. However, difficulty in accurate...
5.
Wawro A, Gajera C, Baker S, Lesniak R, Fischer C, Saw N, et al.
Sci Rep
. 2021 Apr;
11(1):8138.
PMID: 33854131
Imbalance of excitatory and inhibitory neurotransmission is implicated in a wide range of psychiatric and neurologic disorders. Here we tested the hypothesis that insertion of a methyl group on the...
6.
Liu Q, Gupta A, Okesli-Armlovich A, Qiao W, Fischer C, Smith M, et al.
Cell Chem Biol
. 2020 May;
27(6):668-677.e9.
PMID: 32442424
Genome-wide analysis of the mode of action of GSK983, a potent antiviral agent, led to the identification of dihydroorotate dehydrogenase as its target along with the discovery that genetic knockdown...
7.
Kim J, Jedrychowski M, Wei W, Fernandez D, Fischer C, Banik S, et al.
Cell Chem Biol
. 2020 May;
27(9):1130-1139.e4.
PMID: 32402239
N-acyl amino acids are a family of cold-inducible circulating lipids that stimulate thermogenesis. Their biosynthesis is mediated by a secreted enzyme called PM20D1. The extracellular mechanisms that regulate PM20D1 or...
8.
Kim J, Terrell S, Li V, Wei W, Fischer C, Long J
Elife
. 2020 Apr;
9.
PMID: 32271712
The N-acyl amino acids are a family of bioactive lipids with pleiotropic physiologic functions, including in energy homeostasis. Their endogenous levels are regulated by an extracellular mammalian N-acyl amino acid...
9.
Yuet K, Liu C, Lynch S, Kuo J, Michaels W, Lee R, et al.
J Am Chem Soc
. 2020 Mar;
142(13):5952-5957.
PMID: 32182063
Several strains associated with nocardiosis, a potentially life-threatening disease, house a nonamodular assembly line polyketide synthase (PKS) that presumably synthesizes an unknown polyketide. Here, we report the discovery and structure...
10.
Liou C, Sirk S, Diaz C, Klein A, Fischer C, Higginbottom S, et al.
Cell
. 2020 Feb;
180(4):717-728.e19.
PMID: 32084341
Consumption of glucosinolates, pro-drug-like metabolites abundant in Brassica vegetables, has been associated with decreased risk of certain cancers. Gut microbiota have the ability to metabolize glucosinolates, generating chemopreventive isothiocyanates. Here,...