Steven J Skates
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Explore the profile of Steven J Skates including associated specialties, affiliations and a list of published articles.
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4951
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Recent Articles
11.
The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring
Batool S, Yekula A, Khanna P, Hsia T, Gamblin A, Ekanayake E, et al.
Cell Rep Med
. 2023 Sep;
4(10):101198.
PMID: 37716353
The emerging field of liquid biopsy stands at the forefront of novel diagnostic strategies for cancer and other diseases. Liquid biopsy allows minimally invasive molecular characterization of cancers for diagnosis,...
12.
Taylor M, Wu C, Fridy P, Zhang S, Senussi Y, Wolters J, et al.
Cancer Discov
. 2023 Sep;
13(12):2532-2547.
PMID: 37698949
Significance: The LINE-1 ORF1p transposon protein is pervasively expressed in many cancers and is a highly specific biomarker of multiple common, lethal carcinomas and their high-risk precursors in tissue and...
13.
Menon U, Gentry-Maharaj A, Burnell M, Ryan A, Singh N, Manchanda R, et al.
Lancet Oncol
. 2023 Sep;
24(9):1018-1028.
PMID: 37657461
Background: In UKCTOCS, there was a decrease in the diagnosis of advanced stage tubo-ovarian cancer but no reduction in deaths in the multimodal screening group compared with the no screening...
14.
Menon U, Gentry-Maharaj A, Burnell M, Ryan A, Kalsi J, Singh N, et al.
Health Technol Assess
. 2023 May;
:1-81.
PMID: 37183782
Background: Ovarian and tubal cancers are lethal gynaecological cancers, with over 50% of the patients diagnosed at advanced stage. Trial Design: Randomised controlled trial involving 27 primary care trusts adjacent...
15.
Taylor M, Connie W, Fridy P, Zhang S, Senussi Y, Wolters J, et al.
bioRxiv
. 2023 Feb;
PMID: 36747644
Improved biomarkers are needed for early cancer detection, risk stratification, treatment selection, and monitoring treatment response. While proteins can be useful blood-based biomarkers, many have limited sensitivity or specificity for...
16.
Sato S, Gillette M, de Santiago P, Kuhn E, Burgess M, Doucette K, et al.
Sci Rep
. 2023 Jan;
13(1):1537.
PMID: 36707610
Long interspersed element 1 (LINE-1) open reading frame 1 protein (ORF1p) expression is a common feature of many cancer types, including high-grade serous ovarian carcinoma (HGSOC). Here, we report that...
17.
Kennedy J, Whiteaker J, Ivey R, Burian A, Chowdhury S, Tsai C, et al.
Anal Chem
. 2022 Jun;
94(27):9540-9547.
PMID: 35767427
Despite advances in proteomic technologies, clinical translation of plasma biomarkers remains low, partly due to a major bottleneck between the discovery of candidate biomarkers and costly clinical validation studies. Due...
18.
Raoof S, Lee R, Jajoo K, Mancias J, Rebbeck T, Skates S
Cancer Epidemiol Biomarkers Prev
. 2022 Mar;
31(6):1139-1145.
PMID: 35320352
More than 75% of cancer-related deaths occur from cancers for which we do not screen. New screening liquid biopsies may help fill these clinical gaps, although evidence of benefit still...
19.
Lopez L, Nguyen T, Weber G, Kleimola K, Bereda M, Liu Y, et al.
PLoS One
. 2021 Jun;
16(6):e0243676.
PMID: 34111144
Since March 2020, the United States has lost over 580,000 lives to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. A growing body of literature describes population-level SARS-CoV-2...
20.
Menon U, Gentry-Maharaj A, Burnell M, Singh N, Ryan A, Karpinskyj C, et al.
Lancet
. 2021 May;
397(10290):2182-2193.
PMID: 33991479
Background: Ovarian cancer continues to have a poor prognosis with the majority of women diagnosed with advanced disease. Therefore, we undertook the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)...