Steven J Gamblin
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Explore the profile of Steven J Gamblin including associated specialties, affiliations and a list of published articles.
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Recent Articles
21.
Vaswani R, Gehling V, Dakin L, Cook A, Nasveschuk C, Duplessis M, et al.
J Med Chem
. 2016 Oct;
59(21):9928-9941.
PMID: 27739677
Polycomb repressive complex 2 (PRC2) has been shown to play a major role in transcriptional silencing in part by installing methylation marks on lysine 27 of histone 3. Dysregulation of...
22.
Kallewaard N, Corti D, Collins P, Neu U, McAuliffe J, Benjamin E, et al.
Cell
. 2016 Jul;
166(3):596-608.
PMID: 27453466
Influenza virus remains a threat because of its ability to evade vaccine-induced immune responses due to antigenic drift. Here, we describe the isolation, evolution, and structure of a broad-spectrum human...
23.
Justin N, Zhang Y, Tarricone C, Martin S, Chen S, Underwood E, et al.
Nat Commun
. 2016 Apr;
7:11316.
PMID: 27121947
Polycomb repressive complex 2 (PRC2) silences gene expression through trimethylation of K27 of histone H3 (H3K27me3) via its catalytic SET domain. A missense mutation in the substrate of PRC2, histone...
24.
Xiao B, Gamblin S, Wilson J
Enzymes
. 2016 Jan;
24:155-78.
PMID: 26718040
Methylation of lysine residues is now understood to constitute a key component of the complex signaling paradigm referred to as the histone code hypothesis. Rapid progress has been made in...
25.
Zhang Y, Mittal A, Reid J, Reich S, Gamblin S, Wilson J
Structure
. 2015 Sep;
23(10):1921-1933.
PMID: 26320581
Methylation of histone H3 lysine-4 is a hallmark of chromatin associated with active gene expression. The activity of H3K4-specific modification enzymes, in higher eukaryotes the MLL (or KMT2) family, is...
26.
Xiong X, Corti D, Liu J, Pinna D, Foglierini M, Calder L, et al.
Proc Natl Acad Sci U S A
. 2015 Jul;
112(30):9430-5.
PMID: 26170284
H5N1 avian influenza viruses remain a threat to public health mainly because they can cause severe infections in humans. These viruses are widespread in birds, and they vary in antigenicity...
27.
Collins P, Vachieri S, Haire L, Ogrodowicz R, Martin S, Walker P, et al.
Proc Natl Acad Sci U S A
. 2014 Jul;
111(30):11175-80.
PMID: 25024224
In 2004 an hemagglutinin 3 neuraminidase 8 (H3N8) equine influenza virus was transmitted from horses to dogs in Florida and subsequently spread throughout the United States and to Europe. To...
28.
Xiong X, Xiao H, Martin S, Coombs P, Liu J, Collins P, et al.
Virology
. 2014 Jun;
456-457:179-87.
PMID: 24889237
Mutant H5N1 influenza viruses have been isolated from humans that have increased human receptor avidity. We have compared the receptor binding properties of these mutants with those of wild-type viruses,...
29.
Vachieri S, Xiong X, Collins P, Walker P, Martin S, Haire L, et al.
Nature
. 2014 May;
511(7510):475-7.
PMID: 24870229
H10N8 follows H7N9 and H5N1 as the latest in a line of avian influenza viruses that cause serious disease in humans and have become a threat to public health. Since...
30.
Xiao B, Sanders M, Carmena D, Bright N, Haire L, Underwood E, et al.
Nat Commun
. 2013 Dec;
4:3017.
PMID: 24352254
AMP-activated protein kinase (AMPK) plays a major role in regulating cellular energy balance by sensing and responding to increases in AMP/ADP concentration relative to ATP. Binding of AMP causes allosteric...