Steven J Gamblin
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Explore the profile of Steven J Gamblin including associated specialties, affiliations and a list of published articles.
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60
Citations
7642
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Recent Articles
11.
Wrobel A, Benton D, Xu P, Roustan C, Martin S, Rosenthal P, et al.
Nat Struct Mol Biol
. 2020 Jul;
27(8):763-767.
PMID: 32647346
SARS-CoV-2 is thought to have emerged from bats, possibly via a secondary host. Here, we investigate the relationship of spike (S) glycoprotein from SARS-CoV-2 with the S protein of a...
12.
Gamblin S, Vachieri S, Xiong X, Zhang J, Martin S, Skehel J
Cold Spring Harb Perspect Med
. 2020 Jun;
11(10).
PMID: 32513673
Hemagglutinins (HAs) are the receptor-binding and membrane fusion glycoproteins of influenza viruses. They recognize sialic acid-containing, cell-surface glycoconjugates as receptors but have limited affinity for them, and, as a consequence,...
13.
Benton D, Gamblin S, Rosenthal P, Skehel J
Nature
. 2020 May;
583(7814):150-153.
PMID: 32461688
Infection by enveloped viruses involves fusion of their lipid envelopes with cellular membranes to release the viral genome into cells. For HIV, Ebola, influenza and numerous other viruses, envelope glycoproteins...
14.
Beltran M, Tavares M, Justin N, Khandelwal G, Ambrose J, Foster B, et al.
Nat Struct Mol Biol
. 2019 Nov;
26(12):1184-1186.
PMID: 31695189
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
15.
Beltran M, Tavares M, Justin N, Khandelwal G, Ambrose J, Foster B, et al.
Nat Struct Mol Biol
. 2019 Sep;
26(10):899-909.
PMID: 31548724
Polycomb repressive complex 2 (PRC2) maintains repression of cell-type-specific genes but also associates with genes ectopically in cancer. While it is currently unknown how PRC2 is removed from genes, such...
16.
17.
Benton D, Nans A, Calder L, Turner J, Neu U, Lin Y, et al.
Proc Natl Acad Sci U S A
. 2018 Sep;
115(40):10112-10117.
PMID: 30224494
Viruses with membranes fuse them with cellular membranes, to transfer their genomes into cells at the beginning of infection. For Influenza virus, the membrane glycoprotein involved in fusion is the...
18.
Mittal A, Hobor F, Zhang Y, Martin S, Gamblin S, Ramos A, et al.
Nucleic Acids Res
. 2018 Jun;
46(7):3802-3812.
PMID: 29897600
The multi-protein complex WRAD, formed by WDR5, RbBP5, Ash2L and Dpy30, binds to the MLL SET domain to stabilize the catalytically active conformation required for histone H3K4 methylation. In addition,...
19.
Willows R, Sanders M, Xiao B, Patel B, Martin S, Read J, et al.
Biochem J
. 2017 Jul;
474(17):3059-3073.
PMID: 28694351
AMP-activated protein kinase (AMPK) plays a major role in regulating metabolism and has attracted significant attention as a therapeutic target for treating metabolic disorders. AMPK activity is stimulated more than...
20.
Zhang Y, Justin N, Wilson J, Gamblin S
Science
. 2016 Dec;
354(6319):1543.
PMID: 28008037
Jiao and Liu (Research Articles, 16 October 2015, aac4383) reported the crystal structure of the protein complex polycomb repressive complex 2 from Chaetomium thermophilum This landmark structure has brought invaluable...