Philip A Walker
Overview
Explore the profile of Philip A Walker including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
4175
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Recent Articles
1.
Withers-Martinez C, George R, Ogrodowicz R, Kunzelmann S, Purkiss A, Kjaer S, et al.
J Mol Biol
. 2025 Mar;
437(10):169062.
PMID: 40043835
Plasmodium falciparum plasmepsin X (PMX) has become a target of choice for the development of new antimalarial drugs due to its essential role across the parasite life cycle. Here we...
2.
Bailey C, Sanderson T, Townsley H, Goldman J, Black J, Young G, et al.
Lancet
. 2023 Jun;
402(10395):21-24.
PMID: 37348521
No abstract available.
3.
Ng K, Faulkner N, Cornish G, Rosa A, Harvey R, Hussain S, et al.
Science
. 2020 Nov;
370(6522):1339-1343.
PMID: 33159009
Zoonotic introduction of novel coronaviruses may encounter preexisting immunity in humans. Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we detected preexisting humoral immunity. SARS-CoV-2 spike glycoprotein (S)-reactive antibodies were...
4.
Aitken J, Ambrose K, Barrell S, Beale R, Bineva-Todd G, Biswas D, et al.
Nat Biotechnol
. 2020 Jul;
38(8):1000.
PMID: 32681136
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
5.
Aitken J, Ambrose K, Barrell S, Beale R, Bineva-Todd G, Biswas D, et al.
Nat Biotechnol
. 2020 Jun;
38(8):927-931.
PMID: 32555528
No abstract available.
6.
Pisco J, de Chiara C, Pacholarz K, Garza-Garcia A, Ogrodowicz R, Walker P, et al.
Nat Commun
. 2017 Aug;
8(1):203.
PMID: 28781362
ATP-phosphoribosyltransferase (ATP-PRT) is a hexameric enzyme in conformational equilibrium between an open and seemingly active state and a closed and presumably inhibited form. The structure-function relationship of allosteric regulation in...
7.
Kallewaard N, Corti D, Collins P, Neu U, McAuliffe J, Benjamin E, et al.
Cell
. 2016 Jul;
166(3):596-608.
PMID: 27453466
Influenza virus remains a threat because of its ability to evade vaccine-induced immune responses due to antigenic drift. Here, we describe the isolation, evolution, and structure of a broad-spectrum human...
8.
Justin N, Zhang Y, Tarricone C, Martin S, Chen S, Underwood E, et al.
Nat Commun
. 2016 Apr;
7:11316.
PMID: 27121947
Polycomb repressive complex 2 (PRC2) silences gene expression through trimethylation of K27 of histone H3 (H3K27me3) via its catalytic SET domain. A missense mutation in the substrate of PRC2, histone...
9.
Xiong X, Corti D, Liu J, Pinna D, Foglierini M, Calder L, et al.
Proc Natl Acad Sci U S A
. 2015 Jul;
112(30):9430-5.
PMID: 26170284
H5N1 avian influenza viruses remain a threat to public health mainly because they can cause severe infections in humans. These viruses are widespread in birds, and they vary in antigenicity...
10.
Schwefel D, Boucherit V, Christodoulou E, Walker P, Stoye J, Bishop K, et al.
Cell Host Microbe
. 2015 Apr;
17(4):489-99.
PMID: 25856754
The SAMHD1 triphosphohydrolase inhibits HIV-1 infection of myeloid and resting T cells by depleting dNTPs. To overcome SAMHD1, HIV-2 and some SIVs encode either of two lineages of the accessory...