Steven J Gamblin
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Explore the profile of Steven J Gamblin including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Li W, Cao P, Xu P, Sun F, Wang C, Zhang J, et al.
Cell Biosci
. 2024 Jun;
14(1):81.
PMID: 38886783
Background: Histone ubiquitination modification is emerging as a critical epigenetic mechanism involved in a range of biological processes. In vitro reconstitution of ubiquitinated nucleosomes is pivotal for elucidating the influence...
2.
Le T, Benton D, Wrobel A, Gamblin S
RSC Adv
. 2023 May;
13(22):15322-15326.
PMID: 37213341
We have developed broadly reactive aptamers against multiple variants by alternating the target between spike proteins from different SARS-CoV-2 variants during the selection process. In this process we have developed...
3.
Jaki L, Weigang S, Kern L, Kramme S, Wrobel A, Grawitz A, et al.
Nat Commun
. 2023 Apr;
14(1):1999.
PMID: 37037847
Monoclonal antibodies (mAbs) directed against the spike of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are effective therapeutic options to combat infections in high-risk patients. Here, we report the adaptation...
4.
Garcia-Moro E, Zhang J, Calder L, Brown N, Gamblin S, Skehel J, et al.
Proc Natl Acad Sci U S A
. 2022 Aug;
119(33):e2208011119.
PMID: 35939703
The subunits of the influenza hemagglutinin (HA) trimer are synthesized as single-chain precursors (HA0s) that are proteolytically cleaved into the disulfide-linked polypeptides HA1 and HA2. Cleavage is required for activation...
5.
Wrobel A, Benton D, Roustan C, Borg A, Hussain S, Martin S, et al.
Nat Commun
. 2022 Mar;
13(1):1178.
PMID: 35246509
Recently emerged variants of SARS-CoV-2 contain in their surface spike glycoproteins multiple substitutions associated with increased transmission and resistance to neutralising antibodies. We have examined the structure and receptor binding...
6.
Benton D, Wrobel A, Roustan C, Borg A, Xu P, Martin S, et al.
Proc Natl Acad Sci U S A
. 2021 Feb;
118(9).
PMID: 33579792
The majority of currently circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses have mutant spike glycoproteins that contain the D614G substitution. Several studies have suggested that spikes with this...
7.
Wrobel A, Benton D, Xu P, Calder L, Borg A, Roustan C, et al.
Nat Commun
. 2021 Feb;
12(1):837.
PMID: 33547281
Coronaviruses of bats and pangolins have been implicated in the origin and evolution of the pandemic SARS-CoV-2. We show that spikes from Guangdong Pangolin-CoVs, closely related to SARS-CoV-2, bind strongly...
8.
Wrobel A, Benton D, Hussain S, Harvey R, Martin S, Roustan C, et al.
Nat Commun
. 2020 Oct;
11(1):5337.
PMID: 33087721
The CR3022 antibody, selected from a group of SARS-CoV monoclonal antibodies for its ability to cross-react with SARS-CoV-2, has been examined for its ability to bind to the ectodomain of...
9.
Benton D, Wrobel A, Xu P, Roustan C, Martin S, Rosenthal P, et al.
Nature
. 2020 Sep;
588(7837):327-330.
PMID: 32942285
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is initiated by virus binding to the ACE2 cell-surface receptors, followed by fusion of the virus and cell membranes to release...
10.
Wrobel A, Benton D, Xu P, Roustan C, Martin S, Rosenthal P, et al.
Nat Struct Mol Biol
. 2020 Aug;
27(10):1001.
PMID: 32848232
An amendment to this paper has been published and can be accessed via a link at the top of the paper.