Steven I Reed
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Explore the profile of Steven I Reed including associated specialties, affiliations and a list of published articles.
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56
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2509
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Recent Articles
21.
Baskerville C, Segal M, Reed S
Genetics
. 2008 Apr;
178(4):2361-72.
PMID: 18430955
Separase is a caspase-family protease required for the metaphase-anaphase transition in eukaryotes. In budding yeast, the separase ortholog, Esp1, has been shown to cleave a subunit of cohesin, Mcd1 (Scc1),...
22.
Sangfelt O, Cepeda D, Malyukova A, van Drogen F, Reed S
Cell Cycle
. 2008 Apr;
7(8):1075-82.
PMID: 18414042
The ubiquitin-mediated turnover of cyclin E is regulated by phosphorylation and the activity of the ubiquitin ligase SCF(Cdc4) (also known as SCF(Fbw7)). In 293A cells, SCF complexes containing two different...
23.
Reed S
Cancer Cell
. 2008 Feb;
13(2):88-9.
PMID: 18242509
The F box protein Skp2 is frequently overexpressed in human tumors and is capable of transforming cultured cells in vitro. It has been assumed, quite reasonably, that this oncogenic property...
24.
Olson B, Hock M, Ekholm-Reed S, Wohlschlegel J, Dev K, Kralli A, et al.
Genes Dev
. 2008 Jan;
22(2):252-64.
PMID: 18198341
Peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator-1alpha (PGC-1alpha) is a highly regulated transcriptional coactivator that coordinates energy metabolism in mammals. Misregulation of PGC-1alpha has been implicated in the pathogenesis of several...
25.
Akhoondi S, Sun D, von der Lehr N, Apostolidou S, Klotz K, Maljukova A, et al.
Cancer Res
. 2007 Oct;
67(19):9006-12.
PMID: 17909001
The ubiquitin-proteasome system is a major regulatory pathway of protein degradation and plays an important role in cellular division. Fbxw7 (or hCdc4), a member of the F-box family of proteins,...
26.
Keck J, Summers M, Tedesco D, Ekholm-Reed S, Chuang L, Jackson P, et al.
J Cell Biol
. 2007 Aug;
178(3):371-85.
PMID: 17664332
Overexpression of cyclin E, an activator of cyclin-dependent kinase 2, has been linked to human cancer. In cell culture models, the forced expression of cyclin E leads to aneuploidy and...
27.
Keller U, Old J, Dorsey F, Nilsson J, Nilsson L, Maclean K, et al.
EMBO J
. 2007 Apr;
26(10):2562-74.
PMID: 17464290
Reduced levels of the cyclin-dependent kinase inhibitor p27(Kip1) connote poor prognosis in cancer. In human Burkitt lymphoma and in precancerous B cells and lymphomas arising in Emu-Myc transgenic mice, p27(Kip1)...
28.
Reed S
Cell Cycle
. 2006 Aug;
5(17):1923-4.
PMID: 16929178
The recent description of a role for an SCF ubiquitin ligase in prolyl isomerization rather than ubiquitin ligation has led to a 2-step model for inactivation of cyclin E and,...
29.
Reed S
Results Probl Cell Differ
. 2006 Aug;
42:147-81.
PMID: 16903211
Ubiquitin-mediated proteolysis is one of the key mechanisms underlying cell cycle control. The removal of barriers posed by accumulation of negative regulators, as well as the clearance of proteins when...
30.
Spruck C, Sun D, Fiegl H, Marth C, Mueller-Holzner E, Goebel G, et al.
Cancer Res
. 2006 Jul;
66(14):7355-60.
PMID: 16849587
Cyclin E1 regulates the initiation of the S phase program in the mammalian cell division cycle. In normal cells, cyclin E1 protein expression is tightly controlled through a combination of...