Steven Henikoff
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Explore the profile of Steven Henikoff including associated specialties, affiliations and a list of published articles.
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270
Citations
29967
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Recent Articles
1.
Khyzha N, Ahmad K, Henikoff S
Mol Cell
. 2025 Mar;
PMID: 40073862
Nuclear compartments are membrane-less regions enriched in functionally related molecules. RNA is a major component of many nuclear compartments, but the identity and dynamics of transcripts within nuclear compartments are...
2.
Henikoff S, Levens D
Elife
. 2025 Mar;
14.
PMID: 40028765
A new method for mapping torsion provides insights into the ways that the genome responds to the torsion generated by RNA polymerase II.
3.
Fang H, Tronco A, Bonora G, Nguyen T, Thakur J, Berletch J, et al.
BMC Biol
. 2025 Mar;
23(1):68.
PMID: 40025499
Background: Genes that escape X-chromosome inactivation (XCI) in female somatic cells vary in number and levels of escape among mammalian species and tissues, potentially contributing to species- and tissue-specific sex...
4.
Henikoff S, Zheng Y, Paranal R, Xu Y, Greene J, Henikoff J, et al.
Science
. 2025 Feb;
387(6735):737-743.
PMID: 39946483
Genome-wide hypertranscription is common in human cancer and predicts poor prognosis. To understand how hypertranscription might drive cancer, we applied our formalin-fixed paraffin-embedded (FFPE)-cleavage under targeted accessible chromatin method for...
5.
Dekker J, Oksuz B, Zhang Y, Wang Y, Minsk M, Kuang S, et al.
bioRxiv
. 2024 Nov;
PMID: 39484446
The dynamic three-dimensional (3D) organization of the human genome (the "4D Nucleome") is closely linked to genome function. Here, we integrate a wide variety of genomic data generated by the...
6.
Janssens D, Duran M, Otto D, Wu W, Xu Y, Kirkey D, et al.
Nat Commun
. 2024 Oct;
15(1):9341.
PMID: 39472576
Chromosomal translocations involving the mixed-lineage leukemia (MLL) locus generate potent oncogenic fusion proteins (oncoproteins) that disrupt regulation of developmental gene expression. By profiling the oncoprotein-target sites of 36 broadly representative...
7.
Showman S, Talbert P, Xu Y, Henikoff S
STAR Protoc
. 2024 Jul;
5(3):103218.
PMID: 39068651
Centromere length changes occurring during somatic cell divisions can be estimated by quantifying the copy numbers (CNs) of higher-order repeats (HORs), which are nested repeats of monomers that comprise centromeric...
8.
Neefjes J, Gurova K, Sarthy J, Szabo G, Henikoff S
Trends Cancer
. 2024 Jun;
10(8):696-707.
PMID: 38825423
Recent genome-wide analyses identified chromatin modifiers as one of the most frequently mutated classes of genes across all cancers. However, chemotherapies developed for cancers involving DNA damage remain the standard...
9.
Ahmad K, Brahma S, Henikoff S
Mol Cell
. 2024 Apr;
84(10):1818.
PMID: 38604173
No abstract available.
10.
Henikoff S, Zheng Y, Paranal R, Xu Y, Greene J, Henikoff J, et al.
bioRxiv
. 2024 Apr;
PMID: 38559075
Genome-wide hypertranscription is common in human cancer and predicts poor prognosis. To understand how hypertranscription might drive cancer, we applied our FFPE-CUTAC method for mapping RNA Polymerase II (RNAPII) genome-wide...