Steven H Seeholzer
Overview
Explore the profile of Steven H Seeholzer including associated specialties, affiliations and a list of published articles.
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Articles
54
Citations
1332
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Recent Articles
1.
Bagashev A, Sotillo E, Tang C, Black K, Perazzelli J, Seeholzer S, et al.
Mol Cell Biol
. 2022 Aug;
42(9):e0032822.
PMID: 35976030
No abstract available.
2.
Yehya N, Fazelinia H, Taylor D, Lawrence G, Spruce L, Thompson J, et al.
Am J Physiol Lung Cell Mol Physiol
. 2022 Jan;
322(3):L365-L372.
PMID: 34984927
Both sepsis and acute respiratory distress syndrome (ARDS) rely on imprecise clinical definitions leading to heterogeneity, which has contributed to negative trials. Because circulating protein/DNA complexes have been implicated in...
3.
Zamani P, Proto E, Wilson N, Fazelinia H, Ding H, Spruce L, et al.
ESC Heart Fail
. 2021 May;
8(4):2698-2712.
PMID: 33991175
Aims: Skeletal muscle (SkM) abnormalities may impact exercise capacity in patients with heart failure with preserved ejection fraction (HFpEF). We sought to quantify differences in SkM oxidative phosphorylation capacity (OxPhos),...
4.
Dar A, Sawada K, Dybas J, Moser E, Lewis E, Park E, et al.
PLoS Biol
. 2021 Feb;
19(2):e3001041.
PMID: 33524014
The capacity for T cells to become activated and clonally expand during pathogen invasion is pivotal for protective immunity. Our understanding of how T cell receptor (TCR) signaling prepares cells...
5.
Oved J, Paris A, Gollomp K, Dai N, Rubey K, Wang P, et al.
Blood
. 2020 Sep;
137(3):392-397.
PMID: 32959045
Neutrophils are critical mediators of host defense in pathogen-induced and sterile inflammation. Excessive neutrophil activation has been associated with increased host pathology through collateral organ damage. The beneficial aspects of...
6.
Field N, Elbulok O, Dybas J, Moser E, Dar A, Spruce L, et al.
Eur J Immunol
. 2020 May;
50(10):1468-1483.
PMID: 32459862
To mount an antipathogen response, CD4 T cells must undergo rapid cell proliferation; however, poorly controlled expansion can result in diseases such as autoimmunity. One important regulator of T-cell activity...
7.
Vais H, Wang M, Mallilankaraman K, Payne R, McKennan C, Lock J, et al.
Elife
. 2020 May;
9.
PMID: 32420875
Modulating cytoplasmic Ca concentration ([Ca]) by endoplasmic reticulum (ER)-localized inositol 1,4,5-trisphosphate receptor (InsPR) Ca-release channels is a universal signaling pathway that regulates numerous cell-physiological processes. Whereas much is known regarding...
8.
Cardinale C, March M, Lin X, Liu Y, Spruce L, Bradfield J, et al.
J Crohns Colitis
. 2020 Apr;
14(5):646-653.
PMID: 32271392
Background And Aims: Among the >240 genetic loci described to date which confer susceptibility to inflammatory bowel disease, a small subset have been fine-mapped to an individual, non-coding single nucleotide...
9.
Iwafuchi M, Cuesta I, Donahue G, Takenaka N, Osipovich A, Magnuson M, et al.
Nat Genet
. 2020 Mar;
52(4):418-427.
PMID: 32203463
Gene network transitions in embryos and other fate-changing contexts involve combinations of transcription factors. A subset of fate-changing transcription factors act as pioneers; they scan and target nucleosomal DNA and...
10.
Dominguez S, Rodriguez G, Fazelinia H, Ding H, Spruce L, Seeholzer S, et al.
J Alzheimers Dis
. 2020 Mar;
74(4):1131-1142.
PMID: 32144982
Approximately two-thirds of those suffering with Alzheimer's disease (AD) are women, however, the biological mechanisms underlying this sex divergence of AD prevalence remain unknown. Previous research has shown sex-specific biochemical...