Alfonso Bellacosa
Overview
Explore the profile of Alfonso Bellacosa including associated specialties, affiliations and a list of published articles.
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Articles
64
Citations
3244
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Recent Articles
1.
Hassan D, Menges C, Testa J, Bellacosa A
J Exp Clin Cancer Res
. 2024 Nov;
43(1):313.
PMID: 39614261
AKT, or protein kinase B, is a central node of the PI3K signaling pathway that is pivotal for a range of normal cellular physiologies that also underlie several pathological conditions,...
2.
Sementino E, Hassan D, Bellacosa A, Testa J
Cancer Res
. 2024 Oct;
84(24):4126-4139.
PMID: 39437156
Nearly a quarter century ago, Hanahan and Weinberg conceived six unifying principles explaining how normal cells transform into malignant tumors. Their provisional set of biological capabilities acquired during tumor development-cancer...
3.
Le B, Vekariya U, Toma M, Nieborowska-Skorska M, Caron M, Gozdecka M, et al.
bioRxiv
. 2024 Oct;
PMID: 39411165
Myeloid malignancies carrying somatic DNMT3A mutations (DNMT3Amut) are usually resistant to standard therapy. DNMT3Amut leukemia cells accumulate toxic DNA double strand breaks (DSBs) and collapsed replication forks, rendering them dependent...
4.
Menges C, Hassan D, Cheung M, Bellacosa A, Testa J
Curr Top Microbiol Immunol
. 2024 Aug;
PMID: 39192048
The AKT kinases are critical signaling molecules that regulate cellular physiology upon the activation of tyrosine kinase receptors and phosphatidylinositol 3-kinases (PI3K). AKT kinases govern many cellular processes considered hallmarks...
5.
Papin C, Ibrahim A, Sabir J, Le Gras S, Stoll I, Albiheyri R, et al.
J Exp Clin Cancer Res
. 2023 Nov;
42(1):301.
PMID: 37957685
Background: Inherited defects in the base-excision repair gene MBD4 predispose individuals to adenomatous polyposis and colorectal cancer, which is characterized by an accumulation of C > T transitions resulting from...
6.
Tricarico R, Madzo J, Scher G, Cohen M, Jelinek J, Maegawa S, et al.
Gastroenterology
. 2023 Feb;
164(6):921-936.e1.
PMID: 36764492
Background & Aims: Aberrant DNA methylation is frequent in colorectal cancer (CRC), but underlying mechanisms and pathologic consequences are poorly understood. Methods: We disrupted active DNA demethylation genes Tet1 and/or...
7.
Prasad R, Yen T, Bellacosa A
Adv Genet (Hoboken)
. 2023 Jan;
2(1):e10033.
PMID: 36618446
DNA methylation is a critical process in the regulation of gene expression with dramatic effects in development and continually expanding roles in oncogenesis. 5-Methylcytosine was once considered to be an...
8.
Masciullo V, Susini T, Corrado G, Stepanova M, Baroni A, Renda I, et al.
Diagnostics (Basel)
. 2022 Oct;
12(10).
PMID: 36292090
Beta-catenin is involved in intercellular adhesion and participates in the Wnt signaling pathway. This study evaluated the expression pattern and prognostic value of β-catenin in a series of endometrial carcinoma...
9.
Kurimchak A, Herrera-Montavez C, Montserrat-Sangra S, Araiza-Olivera D, Hu J, Neumann-Domer R, et al.
Sci Signal
. 2022 Aug;
15(749):eabn2707.
PMID: 36041010
Proteolysis-targeting chimeras (PROTACs) are a promising new class of drugs that selectively degrade cellular proteins of interest. PROTACs that target oncogene products are avidly being explored for cancer therapies, and...
10.
Mancuso P, Tricarico R, Bhattacharjee V, Cosentino L, Kadariya Y, Jelinek J, et al.
Oncogene
. 2022 May;
41(23):3300-3301.
PMID: 35505094
No abstract available.