Steven H Olson
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Explore the profile of Steven H Olson including associated specialties, affiliations and a list of published articles.
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38
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Recent Articles
11.
Nguyen T, OBrien C, Tran M, Olson S, Settineri N, Prusiner S, et al.
Org Lett
. 2021 Apr;
23(10):3823-3827.
PMID: 33929208
The development of a water-soluble iridium catalyst enables the trifluoromethylation of polar small molecules and peptides in DMSO solution or aqueous media. The reaction was optimized in a microtiter plate...
12.
Li Y, Vaz R, Olson S, Munson M, Paras N, Conrad J
European J Org Chem
. 2021 Mar;
2020(36):5828-5832.
PMID: 33692651
The addition of electron deficient radicals to the position of indoles has been described in the literature as opposed to electrophilic addition at the 3 position. Density functional theory calculations...
13.
Grandjean J, Jiu A, West J, Aoyagi A, Droege D, Elepano M, et al.
ACS Med Chem Lett
. 2020 Feb;
11(2):127-132.
PMID: 32071678
Tau prions feature in the brains of patients suffering from Alzheimer's disease and other tauopathies. For the development of therapeutics that target the replication of tau prions, a high-content, fluorescence-based...
14.
Woerman A, Patel S, Kazmi S, Oehler A, Lee J, Mordes D, et al.
PLoS Pathog
. 2020 Feb;
16(2):e1008222.
PMID: 32017806
Multiple system atrophy (MSA), a progressive neurodegenerative disease characterized by autonomic dysfunction and motor impairment, is caused by the self-templated misfolding of the protein α-synuclein. With no treatment currently available,...
15.
Griffin A, Jaishankar P, Grandjean J, Olson S, Renslo A, Baraban S
Brain Commun
. 2019 Nov;
1(1):fcz008.
PMID: 31667472
Dravet syndrome is a life-threatening early-onset epilepsy not well controlled by antiepileptic drugs. Drugs that modulate serotonin (5-HT) signalling, including clemizole, locaserin, trazodone and fenfluramine, have recently emerged as potential...
16.
Woerman A, Oehler A, Kazmi S, Lee J, Halliday G, Middleton L, et al.
Acta Neuropathol
. 2019 Jan;
137(3):437-454.
PMID: 30690664
Previously, we reported that intracranial inoculation of brain homogenate from multiple system atrophy (MSA) patient samples produces neurological disease in the transgenic (Tg) mouse model TgM83, which uses the prion...
17.
OBrien C, Droege D, Jiu A, Gandhi S, Paras N, Olson S, et al.
J Org Chem
. 2018 Jun;
83(16):8926-8935.
PMID: 29940725
The direct cyanomethylation of indoles at the 2- or 3-position was achieved via photoredox catalysis. The versatile nitrile synthon is introduced as a radical generated from bromoacetonitrile, a photocatalyst, and...
18.
Woerman A, Kazmi S, Patel S, Aoyagi A, Oehler A, Widjaja K, et al.
Proc Natl Acad Sci U S A
. 2017 Dec;
115(2):409-414.
PMID: 29279394
In the neurodegenerative disease multiple system atrophy (MSA), α-synuclein misfolds into a self-templating conformation to become a prion. To compare the biological activity of α-synuclein prions in MSA and Parkinson's...
19.
Woerman A, Patel S, Kazmi S, Oehler A, Freyman Y, Espiritu L, et al.
JAMA Neurol
. 2017 Oct;
74(12):1464-1472.
PMID: 29059326
Importance: Accumulation of the protein tau is a defining characteristic of several neurodegenerative diseases. Thorough assessment of transgenic (Tg) mouse lines that replicate this process is critical for establishing the...
20.
Woerman A, Kazmi S, Patel S, Freyman Y, Oehler A, Aoyagi A, et al.
Acta Neuropathol
. 2017 Aug;
135(1):49-63.
PMID: 28849371
In multiple system atrophy (MSA), progressive neurodegeneration results from the protein α-synuclein misfolding into a self-templating prion conformation that spreads throughout the brain. MSA prions are transmissible to transgenic (Tg)...