Steven G Williams
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Explore the profile of Steven G Williams including associated specialties, affiliations and a list of published articles.
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11
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192
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Recent Articles
1.
Jackson C, Liu J, Liu H, Williams S, Anees A, Noor Z, et al.
Cancer Res Commun
. 2025 Feb;
PMID: 40014866
Although HPV-positive OPSCC is associated with better prognosis than HPV-negative disease, ~30% of cases relapse despite curative-intent radiotherapy (+/- chemotherapy). We aimed to develop a proteomic signature associated with risk...
2.
Xavier D, Lucas N, Williams S, Koh J, Ashman K, Loudon C, et al.
Anal Chem
. 2024 Mar;
96(10):4093-4102.
PMID: 38427620
Proteomic analysis by mass spectrometry of small (≤2 mg) solid tissue samples from diverse formats requires high throughput and comprehensive proteome coverage. We developed a nearly universal, rapid, and robust...
3.
Goncalves E, Poulos R, Cai Z, Barthorpe S, Manda S, Lucas N, et al.
Cancer Cell
. 2022 Jul;
40(8):835-849.e8.
PMID: 35839778
The proteome provides unique insights into disease biology beyond the genome and transcriptome. A lack of large proteomic datasets has restricted the identification of new cancer biomarkers. Here, proteomes of...
4.
Poulos R, Hains P, Shah R, Lucas N, Xavier D, Manda S, et al.
Nat Commun
. 2020 Aug;
11(1):3793.
PMID: 32732981
Reproducible research is the bedrock of experimental science. To enable the deployment of large-scale proteomics, we assess the reproducibility of mass spectrometry (MS) over time and across instruments and develop...
5.
Clement M, Nichols J, Collazo J, Terando A, Hines J, Williams S
Ecol Evol
. 2019 Mar;
9(4):1985-2003.
PMID: 30847087
Understanding the relative impact of climate change and land cover change on changes in avian distribution has implications for the future course of avian distributions and appropriate management strategies. Due...
6.
Horga L, Halliwell S, Selas Castineiras T, Wyre C, Matos C, Yovcheva D, et al.
Microb Cell Fact
. 2018 Dec;
17(1):199.
PMID: 30577801
Background: The secretion of recombinant disulfide-bond containing proteins into the periplasm of Gram-negative bacterial hosts, such as E. coli, has many advantages that can facilitate product isolation, quality and activity....
7.
Selas Castineiras T, Williams S, Hitchcock A, Smith D
FEMS Microbiol Lett
. 2018 Jul;
365(15).
PMID: 29982628
Since the emergence of the biopharmaceutical industry in the 1980's, Escherichia coli, has played an important role in the industrial production of recombinant proteins and plasmid DNA for therapeutic use....
8.
Selas Castineiras T, Williams S, Hitchcock A, Cole J, Smith D, Overton T
Sci Rep
. 2018 May;
8(1):6986.
PMID: 29725125
Targeting of recombinant proteins to the Escherichia coli periplasm is a desirable industrial processing tool to allow formation of disulphide bonds, aid folding and simplify recovery. Proteins are targeted across...
9.
Selas Castineiras T, Williams S, Hitchcock A, Cole J, Smith D, Overton T
Microbiology (Reading)
. 2018 Feb;
164(4):440-452.
PMID: 29458685
As high-level recombinant protein production (RPP) exerts a massive stress on the production host, an extensive literature on RPP optimization focuses on separating the growth phase from RPP production once...
10.
Martinuzzi S, Withey J, Pidgeon A, Plantinga A, McKerrow A, Williams S, et al.
Ecol Appl
. 2015 Aug;
25(1):160-71.
PMID: 26255365
Land-use change is a major cause of wildlife habitat loss. Understanding how changes in land-use policies and economic factors can impact future trends in land use and wildlife habitat loss...