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Steven D Creacy

Explore the profile of Steven D Creacy including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 5
Citations 268
Followers 0
Related Specialties
Biochemistry
General Medicine
Biology
Top 10 Co-Authors
Eric D Routh
James P Vaughn
Steven A Akman
Yoshikuni Nagamine
Philip J Smaldino
Roy R Hantgan
Banabihari Giri
Christi Joyner-Butt
Sandra Pauli
Peter E Beerbower
Published In
J Biol Chem
J Vis Exp
Nucleic Acids Res
PLoS One
Affiliations
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Recent Articles
1.
A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1
Routh E, Creacy S, Beerbower P, Akman S, Vaughn J, Smaldino P
J Vis Exp . 2017 Apr; (121). PMID: 28362374
Higher-order nucleic acid structures called G-quadruplexes (G4s, G4 structures) can form in guanine-rich regions of both DNA and RNA and are highly thermally stable. There are >375,000 putative G4-forming sequences...
2.
Mutational Dissection of Telomeric DNA Binding Requirements of G4 Resolvase 1 Shows that G4-Structure and Certain 3'-Tail Sequences Are Sufficient for Tight and Complete Binding
Smaldino P, Routh E, Kim J, Giri B, Creacy S, Hantgan R, et al.
PLoS One . 2015 Jul; 10(7):e0132668. PMID: 26172836
Ends of human chromosomes consist of the six nucleotide repeat d[pTTAGGG]n known as telomeric DNA, which protects chromosomes. We have previously shown that the DHX36 gene product, G4 Resolvase 1...
3.
G4 resolvase 1 tightly binds and unwinds unimolecular G4-DNA
Giri B, Smaldino P, Thys R, Creacy S, Routh E, Hantgan R, et al.
Nucleic Acids Res . 2011 May; 39(16):7161-78. PMID: 21586581
It has been previously shown that the DHX36 gene product, G4R1/RHAU, tightly binds tetramolecular G4-DNA with high affinity and resolves these structures into single strands. Here, we test the ability...
4.
G4 resolvase 1 binds both DNA and RNA tetramolecular quadruplex with high affinity and is the major source of tetramolecular quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell lysates
Creacy S, Routh E, Iwamoto F, Nagamine Y, Akman S, Vaughn J
J Biol Chem . 2008 Oct; 283(50):34626-34. PMID: 18842585
Quadruplex structures that result from stacking of guanine quartets in nucleic acids possess such thermodynamic stability that their resolution in vivo is likely to require specific recognition by specialized enzymes....
5.
The DEXH protein product of the DHX36 gene is the major source of tetramolecular quadruplex G4-DNA resolving activity in HeLa cell lysates
Vaughn J, Creacy S, Routh E, Joyner-Butt C, Jenkins G, Pauli S, et al.
J Biol Chem . 2005 Sep; 280(46):38117-20. PMID: 16150737
G4-DNA is a highly stable alternative DNA structure that can form spontaneously in guanine-rich regions of single-stranded DNA under physiological conditions. Since a number of biological processes create such single-stranded...