Steven C Rothman
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Explore the profile of Steven C Rothman including associated specialties, affiliations and a list of published articles.
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13
Citations
178
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Recent Articles
1.
Hollands K, Baron C, Gibson K, Kelly K, Krasley E, Laffend L, et al.
Metab Eng
. 2018 Dec;
52:232-242.
PMID: 30557615
Oligosaccharides present in human breast milk have been linked to beneficial effects on infant health. Inclusion of these human milk oligosaccharides (HMOs) in infant formula can recapitulate these health benefits....
2.
Hasselwander O, DiCosimo R, You Z, Cheng Q, Rothman S, Suwannakham S, et al.
Int J Food Sci Nutr
. 2017 Mar;
68(7):849-864.
PMID: 28276900
The aim was to develop novel fibres by enzymatic synthesis, to determine their total dietary fibre by AOAC method 2009.01 and to estimate their potential digestibility and assess their digestibility...
3.
de Ruyck J, Janczak M, Neti S, Rothman S, Schubert H, Cornish R, et al.
Chembiochem
. 2014 Jun;
15(10):1452-8.
PMID: 24910111
Isopentenyl diphosphate isomerase (IDI) is a key enzyme in the isoprenoid biosynthetic pathway and is required for all organisms that synthesize isoprenoid metabolites from mevalonate. Type 1 IDI (IDI-1) is...
4.
de Ruyck J, Pouyez J, Rothman S, Poulter D, Wouters J
Biochemistry
. 2008 Aug;
47(35):9051-3.
PMID: 18693754
The N-terminal region is stabilized in the crystal structure of Thermus thermophilus type 2 isopentenyl diphosphate isomerase in complex with inorganic pyrophosphate, providing new insights about the active site and...
5.
Rothman S, Johnston J, Lee S, Walker J, Poulter C
J Am Chem Soc
. 2008 Mar;
130(14):4906-13.
PMID: 18345677
Isopentenyl diphosphate isomerase (IDI) catalyzes the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), the basic building blocks of isoprenoid molecules. Two structurally unrelated classes of IDI are known....
6.
Walker J, Rothman S, Poulter C
J Org Chem
. 2007 Dec;
73(2):726-9.
PMID: 18088143
Type 2 isopentenyl diphosphate isomerase (IDI-2), which catalyzes the interconversion of isopentenyl diphosphate and dimethylallyl diphosphate, contains a tightly bound molecule of FMN. To probe the mechanism of the reaction,...
7.
Johnston J, Walker J, Rothman S, Poulter C
J Am Chem Soc
. 2007 Jun;
129(25):7740-1.
PMID: 17547410
No abstract available.
8.
Rothman S, Helm T, Poulter C
Biochemistry
. 2007 Apr;
46(18):5437-45.
PMID: 17428035
Type II isopentenyl diphosphate (IPP) isomerase catalyzes the interconversion of IPP and dimethylallyl diphosphate (DMAPP). Although the reactions catalyzed by the type II enzyme and the well-studied type I IPP...
9.
de Ruyck J, Rothman S, Poulter C, Wouters J
Biochem Biophys Res Commun
. 2005 Nov;
338(3):1515-8.
PMID: 16269131
Crystal structures of Thermus thermophilus and Bacillus subtilis type 2 IPP isomerases were combined to generate an almost complete model of the FMN-bound structure of the enzyme. In contrast to...
10.
Rothman S, Voorhies M, Kirsch J
Protein Sci
. 2004 Feb;
13(3):763-72.
PMID: 14767072
The Escherichia coli aspartate (AATase) and tyrosine (TATase) aminotransferases share 43% sequence identity and 72% similarity, but AATase has only 0.08% and 0.01% of the TATase activities (k(cat)/K(m)) for tyrosine...