Jack F Kirsch
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Explore the profile of Jack F Kirsch including associated specialties, affiliations and a list of published articles.
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Citations
901
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Recent Articles
1.
Srouji J, Xu A, Park A, Kirsch J, Brenner S
Proteins
. 2016 Dec;
85(5):775-811.
PMID: 27936487
The Nudix homology clan encompasses over 80,000 protein domains from all three domains of life, defined by homology to each other. Proteins with a domain from this clan fall into...
2.
Nguyen V, Park A, Xu A, Srouji J, Brenner S, Kirsch J
Proteins
. 2016 Sep;
84(12):1810-1822.
PMID: 27618147
The nearly 50,000 known Nudix proteins have a diverse array of functions, of which the most extensively studied is the catalyzed hydrolysis of aberrant nucleotide triphosphates. The functions of 171...
3.
Muratore K, Engelhardt B, Srouji J, Jordan M, Brenner S, Kirsch J
Proteins
. 2013 May;
81(9):1593-609.
PMID: 23671031
The subfamily Iα aminotransferases are typically categorized as having narrow specificity toward carboxylic amino acids (AATases), or broad specificity that includes aromatic amino acid substrates (TATases). Because of their general...
4.
Xu A, Desai A, Brenner S, Kirsch J
Anal Biochem
. 2013 Mar;
437(2):178-84.
PMID: 23481913
The common substrate structure for the functionally diverse Nudix protein superfamily is nucleotide-diphosphate-X, where X is a large variety of leaving groups. The substrate specificity is known for less than...
5.
Shultzaberger R, Maerkl S, Kirsch J, Eisen M
PLoS Genet
. 2012 Apr;
8(3):e1002614.
PMID: 22496663
Transcription factors have two functional constraints on their evolution: (1) their binding sites must have enough information to be distinguishable from all other sequences in the genome, and (2) they...
6.
Deu E, Kirsch J
Protein Sci
. 2011 Sep;
20(12):1991-2003.
PMID: 21936010
The existence of low levels of intersubunit communication in homooligomeric enzymes is often difficult to discover, as the identical active sites cannot be probed individually to dissect their interdependent contributions....
7.
Hanes M, Reynolds K, McNamara C, Ghosh P, Bonomo R, Kirsch J, et al.
Proteins
. 2011 Feb;
79(4):1267-76.
PMID: 21294157
Establishing a quantitative understanding of the determinants of affinity in protein-protein interactions remains challenging. For example, TEM-1/β-lactamase inhibitor protein (BLIP) and SHV-1/BLIP are homologous β-lactamase/β-lactamase inhibitor protein complexes with disparate...
8.
Shultzaberger R, Malashock D, Kirsch J, Eisen M
PLoS Genet
. 2010 Aug;
6(7):e1001042.
PMID: 20686658
The biophysical nature of the interaction between a transcription factor and its target sequences in vitro is sufficiently well understood to allow for the effects of DNA sequence alterations on...
9.
Sankararaman S, Sha F, Kirsch J, Jordan M, Sjolander K
Bioinformatics
. 2010 Jan;
26(5):617-24.
PMID: 20080507
Motivation: The identification of catalytic residues is a key step in understanding the function of enzymes. While a variety of computational methods have been developed for this task, accuracies have...
10.
Deu E, Dhoot J, Kirsch J
Biochemistry
. 2008 Dec;
48(2):433-41.
PMID: 19099423
The role of intersubunit side chain-side chain interactions in the stability of the Escherichia coli aspartate aminotransferase (eAATase) homodimer was investigated by directed mutagenesis at 10 different interface contacts. The...