Steven B Coffey
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Explore the profile of Steven B Coffey including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
198
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Recent Articles
1.
DeCicco E, Berritt S, Knauber T, Coffey S, Hou J, Dowling M
J Org Chem
. 2023 Aug;
88(17):12329-12340.
PMID: 37609685
Aryl bromides are known to be challenging substrates in the decarboxylative cross-electrophile coupling with redox-active NHP esters-the majority of such processes utilize aryl iodides. Herein, we describe the development of...
2.
Aspnes G, Bagley S, Coffey S, Conn E, Curto J, Edmonds D, et al.
Bioorg Med Chem Lett
. 2023 Aug;
94:129454.
PMID: 37591316
Activation of the glucagon-like peptide-1 (GLP-1) receptor stimulates insulin release, lowers plasma glucose levels, delays gastric emptying, increases satiety, suppresses food intake, and affords weight loss in humans. These beneficial...
3.
Aspnes G, Coffey S, Darout E, Dechert-Schmitt A, Dullea R, Kamlet A, et al.
Bioorg Med Chem Lett
. 2023 Jun;
92:129394.
PMID: 37379958
Our previous work on the optimization of a new class of small molecule PCSK9 mRNA translation inhibitors focused on empirical optimization of the amide tail region of the lead PF-06446846...
4.
Londregan A, Aitmakhanova K, Bennett J, Byrnes L, Canterbury D, Cheng X, et al.
J Med Chem
. 2022 Dec;
66(1):460-472.
PMID: 36562986
A series of small-molecule YEATS4 binders have been discovered as part of an ongoing research effort to generate high-quality probe molecules for emerging and/or challenging epigenetic targets. Analogues such as...
5.
Futatsugi K, Cabral S, Kung D, Huard K, Lee E, Boehm M, et al.
J Med Chem
. 2022 Nov;
65(22):15000-15013.
PMID: 36322383
Discovery efforts leading to the identification of ervogastat (PF-06865571), a systemically acting diacylglycerol acyltransferase (DGAT2) inhibitor that has advanced into clinical trials for the treatment of non-alcoholic steatohepatitis (NASH) with...
6.
Aspnes G, Menhaji-Klotz E, Boehm M, Londregan A, Lee E, Limberakis C, et al.
Bioorg Med Chem Lett
. 2021 Aug;
50:128320.
PMID: 34400299
The atypical chemokine receptor C-X-C chemokine receptor type 7 (CXCR7) is an attractive therapeutic target for a variety of cardiac and immunological diseases. As a strategy to mitigate known risks...
7.
Futatsugi K, Smith A, Tu M, Raymer B, Ahn K, Coffey S, et al.
J Med Chem
. 2020 Sep;
63(22):13546-13560.
PMID: 32910646
Increased fructose consumption and its subsequent metabolism have been implicated in metabolic disorders such as nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH) and insulin resistance. Ketohexokinase (KHK) converts fructose to...
8.
Sun H, Piotrowski D, Orr S, Warmus J, Wolford A, Coffey S, et al.
PLoS One
. 2018 Nov;
13(11):e0206279.
PMID: 30427871
Two chemotypes were examined in vitro with CYPs 3A4 and 2C19 by molecular docking, metabolic profiles, and intrinsic clearance deuterium isotope effects with specifically deuterated form to assess the potential...
9.
Londregan A, Wei L, Xiao J, Lintner N, Petersen D, Dullea R, et al.
J Med Chem
. 2018 Jun;
61(13):5704-5718.
PMID: 29878763
The optimization of a new class of small molecule PCSK9 mRNA translation inhibitors is described. The potency, physicochemical properties, and off-target pharmacology associated with the hit compound (1) were improved...
10.
Piotrowski D, Futatsugi K, Casimiro-Garcia A, Wei L, Sammons M, Herr M, et al.
J Med Chem
. 2018 Jan;
61(3):1086-1097.
PMID: 29300474
A novel series of morpholine-based nonsteroidal mineralocorticoid receptor antagonists is reported. Starting from a pyrrolidine HTS hit 9 that possessed modest potency but excellect selectivity versus related nuclear hormone receptors,...