Steve Thibault
Overview
Explore the profile of Steve Thibault including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
160
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0
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Recent Articles
1.
Roy S, Fitzgerald K, Lalani A, Lai C, Kim A, Kim J, et al.
J Clin Invest
. 2023 Jun;
133(12).
PMID: 37317970
While the rapid advancement of immunotherapies has revolutionized cancer treatment, only a small fraction of patients derive clinical benefit. Eradication of large, established tumors appears to depend on engaging and...
2.
Sudom A, Talreja S, Danao J, Bragg E, Kegel R, Min X, et al.
J Biol Chem
. 2018 May;
293(32):12634-12646.
PMID: 29794134
Triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor expressed on the surface of microglia, macrophages, dendritic cells, and osteoclasts. The R47H TREM2 variant is a significant...
3.
Min X, Ungureanu D, Maxwell S, Hammaren H, Thibault S, Hillert E, et al.
J Biol Chem
. 2015 Sep;
290(45):27261-27270.
PMID: 26359499
JAK (Janus family of cytoplasmic tyrosine kinases) family tyrosine kinase 2 (TYK2) participates in signaling through cytokine receptors involved in immune responses and inflammation. JAKs are characterized by dual kinase...
4.
Li Z, Wang X, Eksterowicz J, Gribble Jr M, Alba G, Ayres M, et al.
J Med Chem
. 2014 Mar;
57(8):3430-49.
PMID: 24641103
We describe the structural optimization of a lead compound 1 that exhibits dual inhibitory activities against FLT3 and CDK4. A series of pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidine derivatives was synthesized, and SAR analysis, using...
5.
Motani A, Wang Z, Conn M, Siegler K, Zhang Y, Liu Q, et al.
J Biol Chem
. 2009 Jan;
284(12):7673-80.
PMID: 19147488
Retinol-binding protein 4 (RBP4) transports retinol from the liver to extrahepatic tissues, and RBP4 lowering is reported to improve insulin sensitivity in mice. We have identified A1120, a high affinity...