Dhruv Sareen
Overview
Explore the profile of Dhruv Sareen including associated specialties, affiliations and a list of published articles.
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Articles
51
Citations
2460
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Recent Articles
1.
Vidovic D, Shamsaei B, Schurer S, Kogan P, Chojnacki S, Kouril M, et al.
Mol Cell Proteomics
. 2025 Mar;
:100947.
PMID: 40089066
The Library of Integrated Network-based Cellular Signatures (LINCS), an NIH Common Fund program, has cataloged and analyzed cellular function and molecular activity profiles in response to >80,000 perturbing agents that...
2.
Ariyasinghe N, Gupta D, Escopete S, Rai D, Stotland A, Sundararaman N, et al.
Int J Mol Sci
. 2025 Jan;
26(1.
PMID: 39796045
The prevalence of cardiovascular disease varies with sex, and the impact of intrinsic sex-based differences on vasculature is not well understood. Animal models can provide important insights into some aspects...
3.
Ariyasinghe N, Gupta D, Escopete S, Stotland A, Sundararaman N, Ngu B, et al.
bioRxiv
. 2024 Aug;
PMID: 39211096
Significance: In this work, we have differentiated 4 male and 4 female iPSC lines into vascular smooth muscle cells, giving us the ability to identify statistically-significant sex-specific proteomic markers that...
4.
Tsitkov S, Valentine K, Kozareva V, Donde A, Frank A, Lei S, et al.
Nat Commun
. 2024 May;
15(1):3606.
PMID: 38697975
Amyotrophic Lateral Sclerosis (ALS), like many other neurodegenerative diseases, is highly heritable, but with only a small fraction of cases explained by monogenic disease alleles. To better understand sporadic ALS,...
5.
Ariyasinghe N, de Souza Santos R, Gross A, Aghamaleky-Sarvestany A, Kreimer S, Escopete S, et al.
Physiol Genomics
. 2023 Jun;
55(8):324-337.
PMID: 37306406
The vascular endothelium constitutes the inner lining of the blood vessel, and malfunction and injuries of the endothelium can cause cardiovascular diseases as well as other diseases including stroke, tumor...
6.
Even-Zohar N, Metin-Armagan D, Ben-Shlomo A, Sareen D, Melmed S
Stem Cell Res
. 2023 May;
69:103124.
PMID: 37209468
MEN1, an autosomal dominant disorder caused by mutations in the tumor suppressor gene MEN1, manifests with co-occurrence of multiple endocrine/neuroendocrine neoplasms. An iPSC line derived from an index patient carrying...
7.
Workman M, Lim R, Wu J, Frank A, Ornelas L, Panther L, et al.
Neuron
. 2023 Feb;
111(8):1191-1204.e5.
PMID: 36764301
Using induced pluripotent stem cells (iPSCs) to understand the mechanisms of neurological disease holds great promise; however, there is a lack of well-curated lines from a large array of participants....
8.
Matlock A, Vaibhav V, Holewinski R, Venkatraman V, Dardov V, Manalo D, et al.
Sci Data
. 2023 Jan;
10(1):24.
PMID: 36631473
The National Institute of Health (NIH) Library of integrated network-based cellular signatures (LINCS) program is premised on the generation of a publicly available data resource of cell-based biochemical responses or...
9.
Baxi E, Thompson T, Li J, Kaye J, Lim R, Wu J, et al.
Nat Neurosci
. 2022 Feb;
25(2):226-237.
PMID: 35115730
Answer ALS is a biological and clinical resource of patient-derived, induced pluripotent stem (iPS) cell lines, multi-omic data derived from iPS neurons and longitudinal clinical and smartphone data from over...
10.
Li J, Lim R, Kaye J, Dardov V, Coyne A, Wu J, et al.
iScience
. 2021 Nov;
24(11):103221.
PMID: 34746695
Neurodegenerative diseases are challenging for systems biology because of the lack of reliable animal models or patient samples at early disease stages. Induced pluripotent stem cells (iPSCs) could address these...