Stephen X Skapek
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Explore the profile of Stephen X Skapek including associated specialties, affiliations and a list of published articles.
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89
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2656
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Recent Articles
1.
Segal D, Wang X, Mazloom-Farisbaf H, Rajendran D, Butler E, Chen B, et al.
bioRxiv
. 2024 Dec;
PMID: 39713413
Plasticity is a hallmark function of cancer cells, but many of the underlying mechanisms have yet to be discovered. In this study, we identify Caveolin-1, a scaffolding protein that organizes...
2.
Fraire C, Desai K, Obalapuram U, Mendyka L, Rajaram V, Sebastian T, et al.
bioRxiv
. 2024 May;
PMID: 38712047
Mutations in the microRNA processing genes and drive several cancers that resemble embryonic progenitors. To understand how microRNAs regulate tumorigenesis, we ablated or in the developing pineal gland to emulate...
3.
Martin-Giacalone B, Li H, Scheurer M, Casey D, Dugan-Perez S, Marquez-Do D, et al.
JAMA Netw Open
. 2024 Mar;
7(3):e244170.
PMID: 38546643
Importance: Determining the impact of germline cancer-predisposition variants (CPVs) on outcomes could inform novel approaches to testing and treating children with rhabdomyosarcoma. Objective: To assess whether CPVs are associated with...
4.
He F, Bandyopadhyay A, Klesse L, Rogojina A, Chun S, Butler E, et al.
Nat Commun
. 2023 Nov;
14(1):7600.
PMID: 37990009
Subcutaneous patient-derived xenografts (PDXs) are an important tool for childhood cancer research. Here, we describe a resource of 68 early passage PDXs established from 65 pediatric solid tumor patients. Through...
5.
Yang D, Zhou Q, Furman-Cline L, Cheng X, Luo D, Lai H, et al.
JCO Clin Cancer Inform
. 2023 Nov;
7:e2300104.
PMID: 37956387
Purpose: Osteosarcoma research advancement requires enhanced data integration across different modalities and sources. Current osteosarcoma research, encompassing clinical, genomic, protein, and tissue imaging data, is hindered by the siloed landscape...
6.
Rogojina A, Klesse L, Butler E, Kim J, Zhang H, Xiao X, et al.
iScience
. 2023 Nov;
26(11):108171.
PMID: 37915590
Patient-derived xenografts (PDX) remain valuable models for understanding the biology and for developing novel therapeutics. To expand current PDX models of childhood leukemia, we have developed new PDX models from...
7.
Weiss A, Dry S, Maygar C, Cutler A, Lary C, Khoo C, et al.
Pediatr Blood Cancer
. 2023 Jun;
:e30466.
PMID: 37283290
Deregulation of the mTOR pathway may play an important role in tumor biology when the APC/β-catenin pathway is disrupted in desmoid-type fibromatosis (DT). A pilot study was conducted to determine...
8.
Martin-Giacalone B, Richard M, Scheurer M, Khan J, Sok P, Shetty P, et al.
J Natl Cancer Inst
. 2023 Mar;
115(6):733-741.
PMID: 36951526
Background: Relative to other pediatric cancers, survival for rhabdomyosarcoma (RMS) has not improved in recent decades, suggesting the need to enhance risk stratification. Therefore, we conducted a genome-wide association study...
9.
Liu Y, Romero C, Xiao X, Guo L, Zhou X, Applebaum M, et al.
Mol Cell Biol
. 2023 Mar;
43(3):115-129.
PMID: 36941772
deletion or silencing is common across human cancer, reinforcing the general importance of bypassing its tumor suppression in cancer formation or progression. In rhabdomyosarcoma (RMS) and neuroblastoma, two common childhood...
10.
Milewski D, Jung H, Brown G, Liu Y, Somerville B, Lisle C, et al.
Clin Cancer Res
. 2022 Nov;
29(2):364-378.
PMID: 36346688
Purpose: Rhabdomyosarcoma (RMS) is an aggressive soft-tissue sarcoma, which primarily occurs in children and young adults. We previously reported specific genomic alterations in RMS, which strongly correlated with survival; however,...