Stephen Tate
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Explore the profile of Stephen Tate including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
2020
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0
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Recent Articles
1.
Low K, Kok Y, Tate S, Bi X
Anal Chem
. 2025 Feb;
97(9):5118-5125.
PMID: 39999080
A comprehensive characterization of biotherapeutics, mandated by regulatory authorities, requires analyses of a protein drug at multiple structure levels. Such multilevel characterization can be performed by mass spectrometry (MS), with...
2.
Galli M, Liu L, Sim K, Kok Y, Wongtrakul-Kish K, Nguyen-Khuong T, et al.
AMB Express
. 2024 Dec;
14(1):140.
PMID: 39718710
Sodium butyrate (NaBu), well-known as a histone deacetylase inhibitor and for its capacity to impede cell growth, can enhance the production of a specific protein, such as an antibody, in...
3.
Zhang S, Le Blanc J, Larsen B, Colwill K, Burton L, Guna M, et al.
Anal Chim Acta
. 2024 Sep;
1325:343135.
PMID: 39244297
Background: Mass spectrometry (MS)-based proteomics is a powerful tool for identifying and quantifying proteins. However, chimeric spectra caused by the fragmentation of multiple precursors within the same isolation window impair...
4.
Wang Z, Mulleder M, Batruch I, Chelur A, Textoris-Taube K, Schwecke T, et al.
Elife
. 2022 Nov;
11.
PMID: 36449390
The possibility to record proteomes in high throughput and at high quality has opened new avenues for biomedical research, drug discovery, systems biology, and clinical translation. However, high-throughput proteomic experiments...
5.
Gao H, Liu Y, Demichev V, Tate S, Chen C, Zhu J, et al.
J Proteome Res
. 2022 Jun;
21(7):1686-1693.
PMID: 35653712
Scanning SWATH coupled with normal-flow LC has been recently introduced for high-content, high-throughput proteomics analysis, which requires a relatively large amount of sample injection. Here we established the microflow LC...
6.
Van Puyvelde B, Daled S, Willems S, Gabriels R, Gonzalez de Peredo A, Chaoui K, et al.
Sci Data
. 2022 Mar;
9(1):126.
PMID: 35354825
In the last decade, a revolution in liquid chromatography-mass spectrometry (LC-MS) based proteomics was unfolded with the introduction of dozens of novel instruments that incorporate additional data dimensions through innovative...
7.
Messner C, Demichev V, Bloomfield N, Yu J, White M, Kreidl M, et al.
Nat Biotechnol
. 2021 Mar;
39(7):846-854.
PMID: 33767396
Accurate quantification of the proteome remains challenging for large sample series and longitudinal experiments. We report a data-independent acquisition method, Scanning SWATH, that accelerates mass spectrometric (MS) duty cycles, yielding...
8.
Sim K, Liu L, Tan H, Tan K, Ng D, Zhang W, et al.
Sci Data
. 2020 Aug;
7(1):263.
PMID: 32782267
Sequential window acquisition of all theoretical fragment-ion spectra (SWATH) is a data-independent acquisition (DIA) strategy that requires a specific spectral library to generate unbiased and consistent quantitative data matrices of...
9.
Narayanaswamy P, Teo G, Ow J, Lau A, Kaldis P, Tate S, et al.
Mol Omics
. 2020 Jun;
16(5):436-447.
PMID: 32519713
We have developed MetaboKit, a comprehensive software package for compound identification and relative quantification in mass spectrometry-based untargeted metabolomics analysis. In data dependent acquisition (DDA) analysis, MetaboKit constructs a customized...
10.
Lin Q, Low L, Lau A, Chua E, Matsuoka Y, Lian Y, et al.
Sci Rep
. 2019 Oct;
9(1):15240.
PMID: 31645615
Advances in gene editing now allow reverse genetics to be applied to a broad range of biological systems. Ultimately, any modification to coding sequences requires confirmation at the protein level,...