Stephen Safe
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Explore the profile of Stephen Safe including associated specialties, affiliations and a list of published articles.
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314
Citations
9875
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Recent Articles
1.
Hailemariam A, Upadhyay S, Srivastava V, Hafiz Z, Zhang L, Tsui W, et al.
Chem Res Toxicol
. 2025 Mar;
PMID: 40066943
Polyfluoroalkyl substances (PFAS) are widely used industrial compounds that have been identified as contaminants in almost every component of the global ecosystem, and in human studies, higher levels of PFAS...
2.
Upadhyay S, Lee M, Zhang L, Oany A, Mikheeva S, Mikheev A, et al.
Mol Pharmacol
. 2025 Mar;
107(2):100009.
PMID: 40023516
1,1-Bis(3'-indolyl)-1-(3,5-disubstitutedphenyl)methane (DIM-3,5) compounds are dual receptor ligands that bind both orphan nuclear receptor 4A1 (NR4A1) and NR4A2. Knockdown of NR4A1 or NR4A2 by RNA interference in glioblastoma (GBM) cells decreased...
3.
Safe S, Farkas E, Hailemariam A, Oany A, Sivaram G, Tsui W
Cancers (Basel)
. 2025 Jan;
17(2).
PMID: 39858066
The human nuclear receptor (NR) superfamily consists of 48 genes that are ligand-activated transcription factors that play a key role in maintaining cellular homeostasis and in pathophysiology. NRs are important...
4.
Madison C, Debler R, Gallegos P, Hillbrick L, Chapkin R, Safe S, et al.
Behav Pharmacol
. 2024 Dec;
36(1):40-46.
PMID: 39660867
Parkinson's disease (PD), characterized by death of dopaminergic neurons in the substantia nigra, is the second most prevalent progressive neurodegenerative disease. However, the etiology of PD is largely elusive. This...
5.
Johnson S, Yu Z, Li X, Zarei M, Vaziri-Gohar A, Lee M, et al.
Am J Cancer Res
. 2024 Oct;
14(9):4337-4352.
PMID: 39417168
Pancreatic ductal adenocarcinoma (PDAC) patients' express higher levels of the orphan Nuclear Receptor 4A2 (NR4A2, NURR1) compared to normal pancreas and NR4A2 is a prognostic factor for patient survival. Knockdown...
6.
Garcia-Villatoro E, Bomstein Z, Allred K, Callaway E, Safe S, Chapkin R, et al.
Int J Mol Sci
. 2024 Sep;
25(18).
PMID: 39337636
Tertiary lymphoid tissues (TLTs) are adaptive immune structures that develop during chronic inflammation and may worsen or lessen disease outcomes in a context-specific manner. Immune cell activity governing TLT formation...
7.
Debler R, Gallegos P, Ojeda A, Perttula A, Lucio A, Chapkin R, et al.
Neurotoxicology
. 2024 Jun;
103:71-77.
PMID: 38838945
The etiology of major depressive disorder (MDD) remains poorly understood. Our previous studies suggest a role for the aryl hydrocarbon receptor (AhR) in depression. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a toxic environmental...
8.
DelGiorno K, Safe S, Bailey-Lundberg J
Front Oncol
. 2024 May;
14:1411836.
PMID: 38737907
No abstract available.
9.
Rocha S, Gustafson D, Safe S, Tjalkens R
Toxicol Res (Camb)
. 2024 Apr;
13(2):tfae059.
PMID: 38655145
The modified phytochemical derivative, 1,1-bis(3'-indolyl)-1-(-chlorophenyl) methane (C-DIM12), has been identified as a potential therapeutic platform based on its capacity to improve disease outcomes in models of neurodegeneration and cancer. However,...
10.
Safe S, Han H, Jayaraman A, Davidson L, Allred C, Ivanov I, et al.
Receptors (Basel)
. 2024 Apr;
2(1):93-99.
PMID: 38651159
The aryl hydrocarbon receptor (AhR) is overexpressed in many tumor types and exhibits tumor-specific tumor promoter and tumor suppressor-like activity. In colon cancer, most but not all studies suggest that...