Robert S Chapkin
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Explore the profile of Robert S Chapkin including associated specialties, affiliations and a list of published articles.
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217
Citations
5214
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Recent Articles
1.
Hailemariam A, Upadhyay S, Srivastava V, Hafiz Z, Zhang L, Tsui W, et al.
Chem Res Toxicol
. 2025 Mar;
PMID: 40066943
Polyfluoroalkyl substances (PFAS) are widely used industrial compounds that have been identified as contaminants in almost every component of the global ecosystem, and in human studies, higher levels of PFAS...
2.
Diet therapy abates mutant APC and KRas effects by reshaping plasma membrane cholesterol nanodomains
Kim E, Erazo-Oliveras A, Munoz-Vega M, Fuentes N, Salinas M, George M, et al.
Biophys J
. 2024 Dec;
124(3):508-527.
PMID: 39709523
Cholesterol-enriched plasma membrane domains are known to serve as signaling platforms in a diverse array of cellular processes. However, the link between cholesterol homeostasis and mutant APC-KRas-associated colorectal tumorigenesis remains...
3.
Chakrabarti A, Ni Y, Morris E, Salinas M, Chapkin R, Mallick B
J Mach Learn Res
. 2024 Dec;
25.
PMID: 39691937
We consider the problem of clustering grouped data with possibly non-exchangeable groups whose dependencies can be characterized by a known directed acyclic graph. To allow the sharing of clusters among...
4.
Madison C, Debler R, Gallegos P, Hillbrick L, Chapkin R, Safe S, et al.
Behav Pharmacol
. 2024 Dec;
36(1):40-46.
PMID: 39660867
Parkinson's disease (PD), characterized by death of dopaminergic neurons in the substantia nigra, is the second most prevalent progressive neurodegenerative disease. However, the etiology of PD is largely elusive. This...
5.
Garcia-Villatoro E, Bomstein Z, Allred K, Callaway E, Safe S, Chapkin R, et al.
Int J Mol Sci
. 2024 Sep;
25(18).
PMID: 39337636
Tertiary lymphoid tissues (TLTs) are adaptive immune structures that develop during chronic inflammation and may worsen or lessen disease outcomes in a context-specific manner. Immune cell activity governing TLT formation...
6.
Debler R, Gallegos P, Ojeda A, Perttula A, Lucio A, Chapkin R, et al.
Neurotoxicology
. 2024 Jun;
103:71-77.
PMID: 38838945
The etiology of major depressive disorder (MDD) remains poorly understood. Our previous studies suggest a role for the aryl hydrocarbon receptor (AhR) in depression. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a toxic environmental...
7.
Safe S, Han H, Jayaraman A, Davidson L, Allred C, Ivanov I, et al.
Receptors (Basel)
. 2024 Apr;
2(1):93-99.
PMID: 38651159
The aryl hydrocarbon receptor (AhR) is overexpressed in many tumor types and exhibits tumor-specific tumor promoter and tumor suppressor-like activity. In colon cancer, most but not all studies suggest that...
8.
Heravi G, Liu Z, Herroon M, Wilson A, Fan Y, Jiang Y, et al.
bioRxiv
. 2024 Apr;
PMID: 38586033
Monounsaturated fatty acids (MUFAs) play a pivotal role in maintaining endoplasmic reticulum (ER) homeostasis, an emerging hallmark of cancer. However, the role of polyunsaturated fatty acid (PUFAs) desaturation in persistent...
9.
Zhou F, He K, Cai J, Davidson L, Chapkin R, Ni Y
Stat Biosci
. 2024 Jan;
15(3):669-691.
PMID: 38179127
The advances of modern sequencing techniques have generated an unprecedented amount of multi-omics data which provide great opportunities to quantitatively explore functional genomes from different but complementary perspectives. However, distinct...
10.
Edwards M, Freitas D, Hirtzel E, White N, Wang H, Davidson L, et al.
Anal Chem
. 2023 Dec;
95(50):18557-18563.
PMID: 38050376
Lipids are important biomarkers within the field of disease diagnostics and can serve as indicators of disease progression and predictors of treatment effectiveness. Although lipids can provide important insight into...