Stephen Rumbelow
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Explore the profile of Stephen Rumbelow including associated specialties, affiliations and a list of published articles.
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10
Citations
16
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Recent Articles
1.
McMillan C, Druschitz A, Rumbelow S, Borah A, Binici B, Rattray Z, et al.
RSC Pharm
. 2024 Sep;
1(4):841-853.
PMID: 39323767
Lipid nanoparticles (LNPs), most commonly recognised for their role in COVID-19 mRNA vaccines, are important delivery vehicles for nucleic acid (mRNA, siRNA) therapies. The physicochemical attributes, such as size, nucleic...
2.
Marques Borges G, Santos T, Pinto C, Frezard F, Blanco V, Ondei R, et al.
Nanomedicine (Lond)
. 2024 Jan;
19(5):383-396.
PMID: 38293893
To develop nanoemulsions (NEs) loading amphotericin B (AmB) and to evaluate the influence of different excipients on the stability and the supramolecular organization, retention and toxicity of AmB. The NEs...
3.
Spencer C, Duckett C, Rumbelow S, Clench M
Methods Mol Biol
. 2023 Jul;
2688:71-82.
PMID: 37410285
Careful formulation of pharmaceuticals for oral delivery is essential to ensure that the optimal amount of the active ingredient reaches its intended site of action. This chapter demonstrates how mass...
4.
Spencer C, Rumbelow S, Mellor S, Duckett C, Clench M
Pharmaceutics
. 2022 Feb;
14(2).
PMID: 35214096
Absorption studies on oral drugs can be difficult due to the challenge of replicating the complex structure and environment of the GI tract. Drug absorption studies can be conducted using...
5.
Doshi N, Ritchie K, Shobha T, Giddings J, Gregoritza K, Taing R, et al.
Pharm Res
. 2021 Sep;
38(9):1563-1583.
PMID: 34495486
Purpose: To evaluate a modified high purity polysorbate 20 (RO HP PS20)-with lower levels of stearate, palmitate and myristate esters than the non-modified HP PS20-as a surfactant in biopharmaceutical drug...
6.
Penfield K, Rumbelow S
Rapid Commun Mass Spectrom
. 2020 Jan;
34 Suppl 2:e8709.
PMID: 31943438
Polysorbates are used in a variety of applications over a wide range of markets. Simple in concept, these products are complex in actual composition. Mass spectrometry and related techniques have...
7.
Russo C, Brickelbank N, Duckett C, Mellor S, Rumbelow S, Clench M
Anal Chem
. 2018 Jul;
90(16):10031-10038.
PMID: 30024732
The combination of microspotting of analytical and internal standards, matrix sublimation, and recently developed software for quantitative mass spectrometry imaging has been used to develop a high-resolution method for the...
8.
Hoffman B, Taylor L, Rumbelow S, Pinkston J
J Chromatogr A
. 2004 Nov;
1052(1-2):161-6.
PMID: 15527133
Alcohol ethoxylates (AEOs) that contain a wide distribution of oligomers pose a challenge for ultraviolet (UV) absorbance detection due to the fact that the AEOs absorb strongly only in the...
9.
Hoffman B, Taylor L, Rumbelow S, Goff L, Pinkston J
J Chromatogr A
. 2004 Aug;
1043(2):285-90.
PMID: 15330103
Supercritical fluid chromatography (SFC) was used for the analysis of ethoxylated and propoxylated surfactants. Samples were derivatized to phenylated silyl ethers with a disilazane-chlorosilane mixture. Addition of a phenyl group...
10.
Hoffman B, Taylor L, Rumbelow S, Goff L, Pinkston J
J Chromatogr A
. 2004 May;
1034(1-2):207-12.
PMID: 15116932
Supercritical fluid chromatography (SFC) is capable of separating oligomers of alcohol ethoxylates (AEOs) and propoxylates (APOs) samples with pure carbon dioxide. The instrumental conditions, however, needed for separation necessitate both...