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Stephen R Plymate

Explore the profile of Stephen R Plymate including associated specialties, affiliations and a list of published articles. Areas
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Articles 117
Citations 8616
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Recent Articles
11.
Choi S, Ribeiro C, Wang Y, Loda M, Plymate S, Uo T
Biomolecules . 2022 Nov; 12(11). PMID: 36358940
There is an urgent need for exploring new actionable targets other than androgen receptor to improve outcome from lethal castration-resistant prostate cancer. Tumor metabolism has reemerged as a hallmark of...
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Sowalsky A, Figueiredo I, Lis R, Coleman I, Gurel B, Bogdan D, et al.
Clin Cancer Res . 2022 Jun; 28(16):3509-3525. PMID: 35695870
Purpose: Therapies targeting the androgen receptor (AR) have improved the outcome for patients with castration-sensitive prostate cancer (CSPC). Expression of the constitutively active AR splice variant-7 (AR-V7) has shown clinical...
14.
Plymate S, Sprenger C, Haffner M
Cell Rep Med . 2022 Mar; 3(2):100493. PMID: 35243412
Metastatic prostate cancer remains uncurable. In this issue of , Rice et al. present an assessment of a compound (SU086) demonstrating activity in prostate cancer models through heat shock protein...
15.
Nyquist M, Ang L, Corella A, Coleman I, Meers M, Christiani A, et al.
J Clin Invest . 2021 Jun; 131(12). PMID: 34128479
No abstract available.
16.
Nyquist M, Ang L, Corella A, Coleman I, Meers M, Christiani A, et al.
J Clin Invest . 2021 May; 131(10). PMID: 33998604
Prostate cancer (PC) is driven by androgen receptor (AR) activity, a master regulator of prostate development and homeostasis. Frontline therapies for metastatic PC deprive the AR of the activating ligands...
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Paschalis A, Welti J, Neeb A, Yuan W, Figueiredo I, Pereira R, et al.
Cancer Res . 2021 Apr; 81(4):1087-1100. PMID: 33822745
Endocrine resistance (EnR) in advanced prostate cancer is fatal. EnR can be mediated by androgen receptor (AR) splice variants, with AR splice variant 7 (AR-V7) arguably the most clinically important...
18.
Brady L, Kriner M, Coleman I, Morrissey C, Roudier M, True L, et al.
Nat Commun . 2021 Mar; 12(1):1426. PMID: 33658518
Metastatic prostate cancer (mPC) comprises a spectrum of diverse phenotypes. However, the extent of inter- and intra-tumor heterogeneity is not established. Here we use digital spatial profiling (DSP) technology to...
19.
Sowalsky A, Sharp A, Trostel S, de Bono J, Plymate S
Cancer Treat Res Commun . 2021 Jan; 28:100218. PMID: 33516656
No abstract available.
20.
Uo T, Sprenger C, Plymate S
Front Oncol . 2020 Nov; 10:580617. PMID: 33163409
Metabolic reprogramming is associated with re/activation and antagonism of androgen receptor (AR) signaling that drives prostate cancer (PCa) progression to castration resistance, respectively. In particular, AR signaling influences the fates...