Stephen P Watson
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Explore the profile of Stephen P Watson including associated specialties, affiliations and a list of published articles.
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41
Citations
590
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Recent Articles
1.
Poulter S, Austin N, Armstrong R, Barnes M, Bucknell S, Higueruelo A, et al.
ACS Med Chem Lett
. 2023 Apr;
14(4):499-505.
PMID: 37077397
HTL0041178 (), a potent GPR52 agonist with a promising pharmacokinetic profile and exhibiting oral activity in preclinical models, has been identified. This molecule was the outcome of a judicious molecular...
2.
Southall S, Banerjee J, Brown J, Butkovic K, Cansfield A, Cansfield J, et al.
ACS Med Chem Lett
. 2022 Nov;
13(11):1776-1782.
PMID: 36385934
The diastereomeric macrocyclic calcitonin gene-related peptide (CGRP) antagonists HTL0029881 () and HTL0029882 (), in which the stereochemistry of a spiro center is reversed, surprisingly demonstrate comparable potency. X-ray crystallographic characterization...
3.
Cansfield A, Ator M, Banerjee J, Bestwick M, Bortolato A, Brown G, et al.
ACS Chem Neurosci
. 2022 Mar;
13(6):751-765.
PMID: 35245037
A series of macrocyclic calcitonin gene-related peptide (CGRP) receptor antagonists identified using structure-based design principles, exemplified by HTL0028016 () and HTL0028125 (), is described. Structural characterization by X-ray crystallography of...
4.
Chayoua W, Nicolson P, Meijers J, Kardeby C, Garcia-Quintanilla L, Devreese K, et al.
J Thromb Haemost
. 2021 Mar;
19(7):1776-1782.
PMID: 33774918
Background: Arterial and venous thrombosis are both common in antiphospholipid syndrome (APS). Recent studies have shown that anti-factor Xa (FXa) therapy in APS patients leads to a greater number of...
5.
Kardeby C, Damaskinaki F, Sun Y, Watson S
Platelets
. 2020 Dec;
32(6):779-785.
PMID: 33356751
Platelet Endothelial Aggregation Receptor 1 (PEAR1) is an orphan receptor of unknown function which mediates powerful activation of platelets and endothelial cells in response to crosslinking by antibodies and sulfated...
6.
Zuidscherwoude M, Haining E, Simms V, Watson S, Grygielska B, Hardy A, et al.
Platelets
. 2020 Sep;
32(8):1051-1062.
PMID: 32981398
An organized and dynamic cytoskeleton is required for platelet formation and function. Formins are a large family of actin regulatory proteins which are also able to regulate microtubule dynamics. There...
7.
Vogtle T, Baig A, Volz J, Duchow T, Pleines I, Dutting S, et al.
Platelets
. 2020 Jan;
31(6):801-811.
PMID: 31948362
Platelets are essential for normal hemostasis; however, pathological conditions can also trigger unwanted platelet activation precipitating thrombosis and ischemic damage of vital organs such as the heart or brain. (GP)VI-...
8.
Hill S, Watson S
Trends Pharmacol Sci
. 2017 Dec;
39(2):91-92.
PMID: 29276072
No abstract available.
9.
Messaoudi K, Ali A, Ishaq R, Palazzo A, Sliwa D, Bluteau O, et al.
Nat Commun
. 2017 Nov;
8(1):1786.
PMID: 29176689
Thrombocytopenia is a major side effect of a new class of anticancer agents that target histone deacetylase (HDAC). Their mechanism is poorly understood. Here, we show that HDAC6 inhibition and...
10.
Smith G, Badolo L, Chell V, Chen I, Christensen K, David L, et al.
Bioorg Med Chem Lett
. 2017 Aug;
27(18):4500-4505.
PMID: 28802631
Leucine-rich repeat kinase 2 (LRRK2) has attracted considerable interest as a therapeutic target for the treatment of Parkinson's disease. Compounds derived from a 2-aminopyridine screening hit were optimised using a...