Stephen M Thirdborough
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Explore the profile of Stephen M Thirdborough including associated specialties, affiliations and a list of published articles.
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20
Citations
587
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Recent Articles
1.
Rogel A, Ibrahim F, Thirdborough S, Renart-Depontieu F, Birts C, Buchan S, et al.
JCI Insight
. 2022 Aug;
7(19).
PMID: 35998045
New strategies that augment T cell responses are required to broaden the therapeutic arsenal against cancer. CD96, TIGIT, and CD226 are receptors that bind to a communal ligand, CD155, and...
2.
Bhome R, Emaduddin M, James V, House L, Thirdborough S, Mellone M, et al.
J Extracell Vesicles
. 2022 May;
11(5):e12226.
PMID: 35595718
Colorectal cancer (CRC) with a mesenchymal gene expression signature has the greatest propensity for distant metastasis and is characterised by the accumulation of cancer-associated fibroblasts in the stroma. We investigated...
3.
Hussain K, Liu R, Smith R, Muller K, Ghorbani M, Macari S, et al.
J Exp Clin Cancer Res
. 2022 Apr;
41(1):131.
PMID: 35392965
Background: Hypoxia is a hallmark of the tumor microenvironment (TME) and in addition to altering metabolism in cancer cells, it transforms tumor-associated stromal cells. Within the tumor stromal cell compartment,...
4.
Yeboah M, Papagregoriou C, Jones D, Chan H, Hu G, McPartlan J, et al.
JCI Insight
. 2020 Sep;
5(18).
PMID: 32870822
Despite advances in identifying the key immunoregulatory roles of many of the human leukocyte immunoglobulin-like receptor (LILR) family members, the function of the inhibitory molecule LILRB3 (ILT5, CD85a, LIR3) remains...
5.
Roghanian A, Hu G, Fraser C, Singh M, Foxall R, Meyer M, et al.
Cancer Immunol Res
. 2019 Aug;
7(11):1876-1890.
PMID: 31451483
Therapy-resistant microenvironments represent a major barrier toward effective elimination of disseminated cancer. Many hematologic and solid tumors are resistant to therapeutic antibodies in the bone marrow (BM), but not in...
6.
Buchan S, Fallatah M, Thirdborough S, Taraban V, Rogel A, Thomas L, et al.
Clin Cancer Res
. 2018 Mar;
24(10):2383-2394.
PMID: 29514845
PD-1 checkpoint blockade has revolutionized the field of cancer immunotherapy, yet the frequency of responding patients is limited by inadequate T-cell priming secondary to a paucity of activatory dendritic cells...
7.
Bhome R, Goh R, Bullock M, Pillar N, Thirdborough S, Mellone M, et al.
Aging (Albany NY)
. 2017 Dec;
9(12):2666-2694.
PMID: 29283887
Colorectal cancer is a global disease with increasing incidence. Mortality is largely attributed to metastatic spread and therefore, a mechanistic dissection of the signals which influence tumor progression is needed....
8.
Turaj A, Hussain K, Cox K, Rose-Zerilli M, Testa J, Dahal L, et al.
Cancer Cell
. 2017 Dec;
32(6):777-791.e6.
PMID: 29198913
Monoclonal antibodies (mAbs) can destroy tumors by recruiting effectors such as myeloid cells, or targeting immunomodulatory receptors to promote cytotoxic T cell responses. Here, we examined the therapeutic potential of...
9.
Rogel A, Willoughby J, Buchan S, Leonard H, Thirdborough S, Al-Shamkhani A
Proc Natl Acad Sci U S A
. 2017 Feb;
114(7):E1178-E1187.
PMID: 28137869
Memory CD8 T cells confer long-term immunity against tumors, and anticancer vaccines therefore should maximize their generation. Multiple memory CD8 T-cell subsets with distinct functional and homing characteristics exist, but...
10.
Chakravarthy A, Henderson S, Thirdborough S, Ottensmeier C, Su X, Lechner M, et al.
J Clin Oncol
. 2016 Nov;
34(34):4132-4141.
PMID: 27863190
Purpose In squamous cell carcinomas of the head and neck (HNSCC), the increasing incidence of oropharyngeal squamous cell carcinomas (OPSCCs) is attributable to human papillomavirus (HPV) infection. Despite commonly presenting...