Stephen M Sims
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Explore the profile of Stephen M Sims including associated specialties, affiliations and a list of published articles.
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49
Citations
1517
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Recent Articles
1.
Gui L, Zhu J, Lu X, Sims S, Lu W, Stathopulos P, et al.
J Mol Biol
. 2018 Apr;
430(12):1773-1785.
PMID: 29705071
Store-operated Ca entry (SOCE) mediated by stromal interacting molecule-1 (STIM1) and Orai1 represents a major route of Ca entry in mammalian cells and is initiated by STIM1 oligomerization in the...
2.
Beaucage K, Pollmann S, Sims S, Dixon S, Holdsworth D
Bone Rep
. 2017 Mar;
5:70-80.
PMID: 28326349
Micro-computed tomography (micro-CT) is used routinely to quantify skeletal tissue mass in small animal models. Our goal was to evaluate repeated micro-CT imaging for monitoring whole-body composition in studies of...
3.
Lorusso D, Nikolov H, Milner J, Ochotny N, Sims S, Dixon S, et al.
Biomed Microdevices
. 2016 Aug;
18(5):78.
PMID: 27523472
We describe a simple fabrication technique - targeted towards non-specialists - that allows for the production of leak-proof polydimethylsiloxane (PDMS) microfluidic devices that are compatible with live-cell microscopy. Thin PDMS...
4.
Zhang L, Lu X, Gui L, Wu Y, Sims S, Wang G, et al.
J Cell Mol Med
. 2016 May;
20(8):1513-22.
PMID: 27222313
Rac1 is a small GTPase and plays key roles in multiple cellular processes including the production of reactive oxygen species (ROS). However, whether Rac1 activation during myocardial ischaemia and reperfusion...
5.
Balint B, Yin H, Chakrabarti S, Chu M, Sims S, Pickering J
Arterioscler Thromb Vasc Biol
. 2015 Mar;
35(5):1254-64.
PMID: 25767275
Objective: Smooth muscle cells (SMCs) in healthy arteries are arranged as a collective. However, in diseased arteries, SMCs commonly exist as individual cells, unconnected to each other. The purpose of...
6.
Jiang M, Murias J, Chrones T, Sims S, Lui E, Noble E
Front Pharmacol
. 2014 Mar;
5:43.
PMID: 24672484
Chronic ginseng treatments have been purported to improve cardiac performance. However reports of acute administration of ginseng on cardiovascular function remain controversial and potential mechanisms are not clear. In this...
7.
Beaucage K, Xiao A, Pollmann S, Grol M, Beach R, Holdsworth D, et al.
Purinergic Signal
. 2013 Nov;
10(2):291-304.
PMID: 24222214
The P2X7 receptor is an ATP-gated cation channel expressed by a number of cell types. We have shown previously that disruption of P2X7 receptor function results in downregulation of osteogenic...
8.
Shugg R, Thomson A, Tanabe N, Kashishian A, Steiner B, Puri K, et al.
J Biol Chem
. 2013 Oct;
288(49):35346-57.
PMID: 24133210
Phosphatidylinositol 3-kinases (PI3K) participate in numerous signaling pathways, and control distinct biological functions. Studies using pan-PI3K inhibitors suggest roles for PI3K in osteoclasts, but little is known about specific PI3K...
9.
Wheal B, Beach R, Tanabe N, Dixon S, Sims S
J Bone Miner Res
. 2013 Aug;
29(3):725-34.
PMID: 23956003
Osteoclasts are multinucleated cells responsible for the resorption of bone and other mineralized tissues during development, physiological remodeling, and pathological bone loss. Osteoclasts have the ability to resorb substrate while...
10.
Costa D, Prowse P, Chrones T, Sims S, Hamilton D, Rizkalla A, et al.
Biomaterials
. 2013 Jul;
34(30):7215-26.
PMID: 23830579
The behavior of bone cells is influenced by the surface chemistry and topography of implants and scaffolds. Our purpose was to investigate how the topography of biomimetic hydroxyapatite (HA) coatings...