Alexey Pereverzev
Overview
Explore the profile of Alexey Pereverzev including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
480
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0
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Recent Articles
1.
Kim B, Wang F, Pereverzev A, Chidiac P, Dixon S
ACS Pharmacol Transl Sci
. 2020 Apr;
2(3):155-167.
PMID: 32259054
The parathyroid hormone 1 receptor (PTH1R) is a Class B G-protein-coupled receptor that is a target for osteoporosis therapeutics. Activated PTH1R couples through Gs to the stimulation of adenylyl cyclase....
2.
Kim B, Pereverzev A, Zhu S, Tong A, Dixon S, Chidiac P
Cell Signal
. 2018 Mar;
46:103-112.
PMID: 29501726
Parathyroid hormone (PTH) activates the PTH/PTH-related peptide receptor (PTH1R) on osteoblasts and other target cells. Mechanical stimulation of cells, including osteoblasts, causes release of nucleotides such as ATP into the...
3.
Grol M, Brooks P, Pereverzev A, Dixon S
Purinergic Signal
. 2016 May;
12(3):509-20.
PMID: 27206526
The P2X7 and Wnt/β-catenin signaling pathways regulate osteoblast differentiation and are critical for the anabolic responses of bone to mechanical loading. However, whether these pathways interact to control osteoblast activity...
4.
Drobinskaya I, Neumaier F, Pereverzev A, Hescheler J, Schneider T
Biochim Biophys Acta
. 2015 Jan;
1853(5):953-64.
PMID: 25603538
Peptide-hormone secretion is partially triggered by Ca2+ influx through voltage-gated Ca2+ channels (VGCCs) and gene inactivation of Zn2+-sensitive Cav2.3-type VGCCs is associated with disturbed glucose homeostasis in mice. Zn2+ has...
5.
Shugg R, Thomson A, Tanabe N, Kashishian A, Steiner B, Puri K, et al.
J Biol Chem
. 2013 Oct;
288(49):35346-57.
PMID: 24133210
Phosphatidylinositol 3-kinases (PI3K) participate in numerous signaling pathways, and control distinct biological functions. Studies using pan-PI3K inhibitors suggest roles for PI3K in osteoclasts, but little is known about specific PI3K...
6.
Grol M, Pereverzev A, Sims S, Dixon S
J Cell Sci
. 2013 Jun;
126(Pt 16):3615-26.
PMID: 23750003
The primordial intercellular signaling molecule ATP acts through two families of cell-surface P2 receptors - the P2Y family of G-protein-coupled receptors and the P2X family of ligand-gated cation channels. Multiple...
7.
Sims S, Panupinthu N, Lapierre D, Pereverzev A, Dixon S
Biochim Biophys Acta
. 2012 Aug;
1831(1):109-16.
PMID: 22892679
Osteoclasts (bone resorbing cells) and osteoblasts (bone forming cells) play essential roles in skeletal development, mineral homeostasis and bone remodeling. The actions of these two cell types are tightly coordinated,...
8.
Lapierre D, Tanabe N, Pereverzev A, Spencer M, Shugg R, Dixon S, et al.
J Biol Chem
. 2010 Jun;
285(33):25792-801.
PMID: 20551326
Lysophosphatidic acid (LPA) is a bioactive phospholipid whose functions are mediated by multiple G protein-coupled receptors. We have shown that osteoblasts produce LPA, raising the possibility that it mediates intercellular...
9.
Armstrong S, Pereverzev A, Dixon S, Sims S
J Cell Sci
. 2008 Dec;
122(Pt 1):136-44.
PMID: 19066285
Nucleotides, released in response to mechanical or inflammatory stimuli, signal through P2 nucleotide receptors in many cell types. Osteoclasts express P2X7 receptors (encoded by P2rx7) - Ca(2+)-permeable channels that are...
10.
Pereverzev A, Komarova S, Korcok J, Armstrong S, Tremblay G, Dixon S, et al.
Bone
. 2007 Oct;
42(1):150-61.
PMID: 17964236
Systemic acidosis has detrimental effects on the skeleton and local acidosis is associated with bone destruction in inflammatory and neoplastic diseases. However, the mechanisms by which acidosis enhances osteoclastic bone...